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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
MSE
251
MUFG Securities EMEA
United Kingdom
$5.96M
BAMF
252
BI Asset Management Fondsmaeglerselskab
Denmark
$5.91M
CGIM
253
Capital Group Investment Management
Singapore
$5.9M
Wealth Enhancement Advisory Services
254
Wealth Enhancement Advisory Services
Minnesota
$5.74M
VPIM
255
Vanguard Personalized Indexing Management
California
$5.46M
Prudential Financial
256
Prudential Financial
New Jersey
$5.29M
CAPTRUST Financial Advisors
257
CAPTRUST Financial Advisors
North Carolina
$5.27M
CM
258
Capula Management
Cayman Islands
$5.24M
Nordea Investment Management
259
Nordea Investment Management
Sweden
$5.12M
RIM
260
Rakuten Investment Management
Japan
$5.06M
PNC Financial Services Group
261
PNC Financial Services Group
Pennsylvania
$5.04M
AIMCA
262
Alberta Investment Management Corp (AIMCo)
Alberta, Canada
$5.01M
FDCDDQ
263
Federation des caisses Desjardins du Quebec
Quebec, Canada
$4.99M
MFAM
264
Motley Fool Asset Management
Virginia
$4.98M
IMPI
265
Ilmarinen Mutual Pension Insurance
Finland
$4.97M
Public Employees Retirement Association of Colorado
266
Public Employees Retirement Association of Colorado
Colorado
$4.95M
Mackenzie Financial
267
Mackenzie Financial
Ontario, Canada
$4.91M
CIBC World Market
268
CIBC World Market
Ontario, Canada
$4.86M
ZIM
269
Zacks Investment Management
Illinois
$4.77M
Mercer Global Advisors
270
Mercer Global Advisors
Colorado
$4.69M
TCM
271
Traynor Capital Management
Pennsylvania
$4.6M
RBI
272
Raiffeisen Bank International
Austria
$4.57M
HFS
273
Hantz Financial Services
Michigan
$4.5M
KCM
274
Kornitzer Capital Management
Kansas
$4.42M
BCV
275
Banque Cantonale Vaudoise
Switzerland
$4.39M