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Alnylam Pharmaceuticals

832 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 283 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 283 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.57B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
832
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
CGIM
251
Capital Group Investment Management
Singapore
$5.9M
Wealth Enhancement Advisory Services
252
Wealth Enhancement Advisory Services
Minnesota
$5.74M
VPIM
253
Vanguard Personalized Indexing Management
California
$5.46M
Prudential Financial
254
Prudential Financial
New Jersey
$5.29M
CAPTRUST Financial Advisors
255
CAPTRUST Financial Advisors
North Carolina
$5.27M
CM
256
Capula Management
Cayman Islands
$5.24M
Nordea Investment Management
257
Nordea Investment Management
Sweden
$5.12M
RIM
258
Rakuten Investment Management
Japan
$5.06M
PNC Financial Services Group
259
PNC Financial Services Group
Pennsylvania
$5.04M
AIMCA
260
Alberta Investment Management Corp (AIMCo)
Alberta, Canada
$5.01M
FDCDDQ
261
Federation des caisses Desjardins du Quebec
Quebec, Canada
$4.99M
MFAM
262
Motley Fool Asset Management
Virginia
$4.98M
IMPI
263
Ilmarinen Mutual Pension Insurance
Finland
$4.97M
Public Employees Retirement Association of Colorado
264
Public Employees Retirement Association of Colorado
Colorado
$4.95M
Mackenzie Financial
265
Mackenzie Financial
Ontario, Canada
$4.91M
CIBC World Market
266
CIBC World Market
Ontario, Canada
$4.86M
ZIM
267
Zacks Investment Management
Illinois
$4.77M
Mercer Global Advisors
268
Mercer Global Advisors
Colorado
$4.69M
TCM
269
Traynor Capital Management
Pennsylvania
$4.6M
RBI
270
Raiffeisen Bank International
Austria
$4.57M
HFS
271
Hantz Financial Services
Michigan
$4.5M
KCM
272
Kornitzer Capital Management
Kansas
$4.42M
BCV
273
Banque Cantonale Vaudoise
Switzerland
$4.39M
CFB
274
Cullen/Frost Bankers
Texas
$4.39M
AV
275
ASR Vermogensbeheer
Netherlands
$4.38M