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Alnylam Pharmaceuticals

839 hedge funds and large institutions have $51.7B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 165 funds opening new positions, 286 increasing their positions, 289 reducing their positions, and 118 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

1% less repeat investments, than reductions

Existing positions increased: 286 | Existing positions reduced: 289

13% less capital invested

Capital invested by funds: $59.2B → $51.7B (-$7.51B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
839
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$494M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$149M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M
5
Morgan Stanley
Morgan Stanley
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
Thrivent Financial for Lutherans
226
Thrivent Financial for Lutherans
Minnesota
$8.21M
FISPB
227
Fideuram - Intesa Sanpaolo Private Banking
$8.14M
Stifel Financial
228
Stifel Financial
Missouri
$8.12M
EGM
229
Engineers Gate Manager
New York
$8.03M
AG
230
AIA Group
Hong Kong
$8.02M
Teacher Retirement System of Texas
231
Teacher Retirement System of Texas
Texas
$7.97M
EF
232
Empowered Funds
Pennsylvania
$7.73M
PFSRSONJ
233
Police & Firemen's Retirement System of New Jersey
New Jersey
$7.67M
LIP
234
Liontrust Investment Partners
United Kingdom
$7.31M
Wealthfront Advisers
235
Wealthfront Advisers
California
$7.26M
SCM
236
Silvant Capital Management
Georgia
$7.14M
VIM
237
Vinva Investment Management
Australia
$7.14M
IGAM
238
iA Global Asset Management
Quebec, Canada
$7.07M
MML Investors Services
239
MML Investors Services
Massachusetts
$7.02M
Cetera Investment Advisers
240
Cetera Investment Advisers
Illinois
$6.98M
EMPI
241
Elo Mutual Pension Insurance
Finland
$6.94M
AGP
242
Artia Global Partners
Florida
$6.92M
PM
243
Prosight Management
Texas
$6.8M
ET
244
Entropy Technologies
New York
$6.4M
AssetMark Inc
245
AssetMark Inc
California
$6.38M
SMDAM
246
Sumitomo Mitsui DS Asset Management
Japan
$6.31M
OAM
247
Oppenheimer Asset Management
New York
$6.2M
PA
248
Profund Advisors
Maryland
$6.2M
MOACM
249
Mutual of America Capital Management
New York
$6.15M
SCM
250
Shelton Capital Management
Colorado
$5.99M