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Alnylam Pharmaceuticals

832 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 283 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 283 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.57B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
832
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
Stifel Financial
226
Stifel Financial
Missouri
$8.12M
EGM
227
Engineers Gate Manager
New York
$8.03M
AG
228
AIA Group
Hong Kong
$8.02M
Teacher Retirement System of Texas
229
Teacher Retirement System of Texas
Texas
$7.97M
EF
230
Empowered Funds
Pennsylvania
$7.73M
PFSRSONJ
231
Police & Firemen's Retirement System of New Jersey
New Jersey
$7.67M
LIP
232
Liontrust Investment Partners
United Kingdom
$7.31M
Wealthfront Advisers
233
Wealthfront Advisers
California
$7.26M
SCM
234
Silvant Capital Management
Georgia
$7.14M
VIM
235
Vinva Investment Management
Australia
$7.14M
IGAM
236
iA Global Asset Management
Quebec, Canada
$7.07M
MML Investors Services
237
MML Investors Services
Massachusetts
$7.02M
Cetera Investment Advisers
238
Cetera Investment Advisers
Illinois
$6.98M
EMPI
239
Elo Mutual Pension Insurance
Finland
$6.94M
AGP
240
Artia Global Partners
Florida
$6.92M
PM
241
Prosight Management
Texas
$6.8M
ET
242
Entropy Technologies
New York
$6.4M
AssetMark Inc
243
AssetMark Inc
California
$6.38M
SMDAM
244
Sumitomo Mitsui DS Asset Management
Japan
$6.31M
OAM
245
Oppenheimer Asset Management
New York
$6.2M
PA
246
Profund Advisors
Maryland
$6.2M
MOACM
247
Mutual of America Capital Management
New York
$6.15M
SCM
248
Shelton Capital Management
Colorado
$5.99M
MSE
249
MUFG Securities EMEA
United Kingdom
$5.96M
BAMF
250
BI Asset Management Fondsmaeglerselskab
Denmark
$5.91M