Alector
ALEC
131 hedge funds and large institutions have $132M invested in Alector in 2025 Q4 according to their latest regulatory filings, with 25 funds opening new positions, 40 increasing their positions, 41 reducing their positions, and 39 closing their positions.
221% more call options, than puts
Call options by funds: $863K | Put options by funds: $269K
3.52% more ownership
Funds ownership: 73.85% → 77.37% (+3.5%)
0% more funds holding in top 10
Funds holding in top 10: 6 → 6 (0)
2% less repeat investments, than reductions
Existing positions increased: 40 | Existing positions reduced: 41
12% less funds holding
Funds holding: 149 → 131 (-18)
36% less first-time investments, than exits
New positions opened: 25 | Existing positions closed: 39
40% less capital invested
Capital invested by funds: $221M → $132M (-$89M)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
TCM
TCG Crossover Management
Palo Alto,
California
|
+$17.7M |
| 2 |
FCMI
Foresite Capital Management IV
Larkspur,
California
|
+$6.9M |
| 3 |
Balyasny Asset Management
Chicago,
Illinois
|
+$5.79M |
| 4 |
6CM
683 Capital Management
New York
|
+$4.17M |
| 5 |
KCM
Kynam Capital Management
Princeton,
New Jersey
|
+$3.55M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Fidelity Investments
Boston,
Massachusetts
|
-$23M |
| 2 |
RI
RTW Investments
New York
|
-$20.7M |
| 3 |
T. Rowe Price Associates
Baltimore,
Maryland
|
-$3.78M |
| 4 |
5VM
5AM Venture Management
San Francisco,
California
|
-$2.95M |
| 5 |
Royal Bank of Canada
Toronto,
Ontario, Canada
|
-$1.11M |
ALEC Hedge Fund Activity: Q4 2025 in Review
131 of the 8,270 institutional investors tracked by Wall St. Rank reported a position in Alector (ALEC) for Q4 2025, worth a combined $132M — down 40% from $221M a quarter earlier.
Sellers outnumbered buyers: 39 funds closed out of ALEC and 25 opened new positions — a net loss of 14 holders — while 41 trimmed existing stakes and 40 added.
The largest buyer was TCG Crossover Management, opening a new position worth an estimated $17.7M. The largest seller was Fidelity Investments, cutting an estimated $23M.
- 131 institutional investors held Alector (ALEC) as of Q4 2025, down from 149 in Q3 2025.
- Funds reported $132M of Alector stock for Q4 2025, down 40% quarter-over-quarter.
- 25 funds opened new Alector positions in Q4 2025 and 39 closed out, a net change of -14 holders.
- The largest Alector buyer in Q4 2025 was TCG Crossover Management, an estimated $17.7M added.
- The largest Alector seller in Q4 2025 was Fidelity Investments, an estimated $23M sold.
Based on aggregated 13F filings for Q4 2025.