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ARDX

Nome Posição Valor negociado Ações
Variação 		Variação na
participação
NEA Management Company
1
NEA Management Company
Maryland
US$ 182 mi +US$ 24 mi +2.290.951 +19%
Fidelity Investments
2
Fidelity Investments
Massachusetts
US$ 51,4 mi -US$ 426 mil -40.704 -1%
RA Capital Management
3
RA Capital Management
Massachusetts
US$ 42,3 mi +US$ 10 mi +953.802 +41%
Cormorant Asset Management
4
Cormorant Asset Management
Massachusetts
US$ 26,8 mi +US$ 6 mi +572.738 +38%
Rock Springs Capital Management
5
Rock Springs Capital Management
Maryland
US$ 25,6 mi +US$ 7,33 mi +700.000 +55%
T. Rowe Price Associates
6
T. Rowe Price Associates
Maryland
US$ 23,8 mi +US$ 3,49 mi +333.278 +22%
BlackRock Fund Advisors
7
BlackRock Fund Advisors
California
US$ 19,5 mi +US$ 4,94 mi +471.594 +46%
EcoR1 Capital
8
EcoR1 Capital
California
US$ 17 mi +US$ 13,7 mi +1.310.023 Nova
Perceptive Advisors
9
Perceptive Advisors
New York
US$ 13,7 mi +US$ 7,77 mi +741.302 +235%
First Manhattan
10
First Manhattan
New York
US$ 13,6 mi +US$ 11 mi +1.053.628 Nova
Vanguard Group
11
Vanguard Group
Pennsylvania
US$ 12,6 mi +US$ 2,79 mi +266.258 +38%
Tekla Capital Management
12
Tekla Capital Management
Massachusetts
US$ 9,16 mi -US$ 7,14 mi -681.734 -49%
Deerfield Management
13
Deerfield Management
New York
US$ 8 mi +US$ 3,6 mi +343.643 +125%
BlackRock Institutional Trust
14
BlackRock Institutional Trust
California
US$ 5,33 mi +US$ 916 mil +87.385 +27%
State Street
15
State Street
Massachusetts
US$ 5,21 mi +US$ 1,4 mi +133.726 +50%
JP Morgan Chase
16
JP Morgan Chase
New York
US$ 5,01 mi +US$ 1,31 mi +124.919 +48%
Millennium Management
17
Millennium Management
New York
US$ 3,95 mi +US$ 3,2 mi +305.246 Nova
Northern Trust
18
Northern Trust
Illinois
US$ 3,83 mi +US$ 475 mil +45.361 +18%
DAFNA Capital Management
19
DAFNA Capital Management
California
US$ 2,84 mi +US$ 1,98 mi +189.095 +630%
WSA
20
Wall Street Associates
California
US$ 2,46 mi +US$ 100 mil +9.500 +5%
Geode Capital Management
21
Geode Capital Management
Massachusetts
US$ 2,23 mi +US$ 265 mil +25.251 +17%
Sphera Funds Management
22
Sphera Funds Management
Israel
US$ 1,96 mi +US$ 1,59 mi +151.813 Nova
BlackRock Investment Management
23
BlackRock Investment Management
Delaware
US$ 1,7 mi +US$ 374 mil +35.683 +37%
Bank of New York Mellon
24
Bank of New York Mellon
New York
US$ 1,3 mi +US$ 11,9 mil +1.139 +1%
AIC
25
AWM Investment Company
New York
US$ 1,29 mi +US$ 1,05 mi +100.000 Nova
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