|
1
|
BVF Inc
San Francisco,
California
|
–
|
-US$ 3,77 mi
|
-16.552.417
|
Encerrada
|
|
|
2
|
Tang Capital Management
San Diego,
California
|
–
|
-US$ 1,98 mi
|
-8.693.687
|
Encerrada
|
|
|
3
|
Deep Track Capital
Greenwich,
Connecticut
|
–
|
-US$ 1,65 mi
|
-7.232.701
|
Encerrada
|
|
|
4
|
NEA Management Company
Timonium,
Maryland
|
–
|
-US$ 1,4 mi
|
-6.147.260
|
Encerrada
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
–
|
-US$ 782 mil
|
-3.428.138
|
Encerrada
|
|
|
6
|
Acadian Asset Management
Boston,
Massachusetts
|
–
|
-US$ 668 mil
|
-2.939.856
|
Encerrada
|
|
|
7
|
Logos Global Management
San Francisco,
California
|
–
|
-US$ 660 mil
|
-2.900.000
|
Encerrada
|
|
|
8
|
Alta Partners Management Company
Jackson,
Wyoming
|
–
|
-US$ 580 mil
|
-2.546.147
|
Encerrada
|
|
|
9
|
|
–
|
-US$ 289 mil
|
-1.268.896
|
Encerrada
|
|
|
10
|
Ikarian Capital
Dallas,
Texas
|
–
|
-US$ 267 mil
|
-1.171.950
|
Encerrada
|
|
|
11
|
Geode Capital Management
Boston,
Massachusetts
|
–
|
-US$ 217 mil
|
-952.290
|
Encerrada
|
|
|
12
|
Renaissance Technologies
New York
|
–
|
-US$ 198 mil
|
-869.311
|
Encerrada
|
|
|
13
|
Redmile Group
San Francisco,
California
|
–
|
-US$ 195 mil
|
-856.615
|
Encerrada
|
|
|
14
|
Vivo Capital
Palo Alto,
California
|
–
|
-US$ 174 mil
|
-765.500
|
Encerrada
|
|
|
15
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
–
|
-US$ 145 mil
|
-629.159
|
Encerrada
|
|
|
16
|
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
–
|
-US$ 111 mil
|
-489.426
|
Encerrada
|
|
|
17
|
Deuterium Capital Management
Clearwater,
Florida
|
–
|
-US$ 108 mil
|
-473.439
|
Encerrada
|
|
|
18
|
GSA Capital Partners
London,
United Kingdom
|
–
|
-US$ 102 mil
|
-449.504
|
Encerrada
|
|
|
19
|
DLD Asset Management
New York
|
–
|
-US$ 99,2 mil
|
-435.668
|
Encerrada
|
|
|
20
|
Boothbay Fund Management
New York
|
–
|
-US$ 73,4 mil
|
-322.697
|
Encerrada
|
|
|
21
|
State Street
Boston,
Massachusetts
|
–
|
-US$ 67 mil
|
-294.525
|
Encerrada
|
|
|
22
|
Fidelity Investments
Boston,
Massachusetts
|
–
|
-US$ 61,8 mil
|
-271.314
|
Encerrada
|
|
|
23
|
Deltec Asset Management
New York
|
–
|
-US$ 58,5 mil
|
-257.127
|
Encerrada
|
|
|
24
|
Affinity Asset Advisors
New York
|
–
|
-US$ 56,9 mil
|
-250.000
|
Encerrada
|
|
|
25
|
Millennium Management
New York
|
–
|
-US$ 41,8 mil
|
-183.562
|
Encerrada
|
|
