Two Sigma Securities’s Mereo BioPharma MREO Stock Holding History

Two Sigma Securities’s Portfolio MREO Stock Details MREO Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$4.1K	Buy	+12,900	New	+$3.87K	﹤0.01%	1602
2024 Q3	–	Sell	-13,926	Closed	-$50.1K	–	3356
2024 Q2	$50.1K	Buy	+13,926	New	+$45.1K	﹤0.01%	2574
2022 Q4	–	Sell	-10,043	Closed	-$9K	–	3017
2022 Q3	$9K	Sell	10,043 -85,768	-90%	-$105K	﹤0.01%	2416
2022 Q2	$107K	Buy	95,811 +81,811	+584%	+$63.4K	﹤0.01%	1743
2022 Q1	$16K	Sell	14,000 -3,899	-22%	-$5.04K	﹤0.01%	2003
2021 Q4	$29K	Buy	+17,899	New	+$35.8K	﹤0.01%	1362

Other funds holding MREO

RCMNY

Rubric Capital Management (New York) New York $10.9B AUM 70.31% 1-Year Est. Return

6CM

683 Capital Management New York $2.04B AUM 94.26% 1-Year Est. Return

Bank of America Charlotte, North Carolina $1.55T AUM 33.47% 1-Year Est. Return

DCM

Defilade Capital Management Emeryville, California $747M AUM

Newtyn Management New York $801M AUM 23.14% 1-Year Est. Return

Tejara Capital London, United Kingdom $243M AUM 9.84% 1-Year Est. Return

UBS Group Zurich, Switzerland $786B AUM 40.34% 1-Year Est. Return

Two Sigma Investments New York $138B AUM 41.87% 1-Year Est. Return

EcoR1 Capital San Francisco, California $2.06B AUM 215.32% 1-Year Est. Return

Jane Street New York $1.21T AUM 78.12% 1-Year Est. Return

Two Sigma Securities's MREO Position: Q2 2026 in Review

Two Sigma Securities opened a new position in Mereo BioPharma (MREO) in Q2 2026: 12,900 shares worth $4.1K. The stake represents ﹤0.01% of the portfolio and ranks #1602 among its holdings. This is a return to the name: Two Sigma Securities previously reported a position in MREO as recently as Q2 2024.

Two Sigma Securities first reported a position in MREO in Q4 2021 and has held it in 6 quarters since. The position peaked at $107K in Q2 2022. 60 funds tracked by Wall St. Rank hold MREO as of Q2 2026.

Two Sigma Securities held 12,900 shares of Mereo BioPharma worth $4.1K as of Q2 2026.
Mereo BioPharma was a new Two Sigma Securities position in Q2 2026.
Mereo BioPharma made up ﹤0.01% of Two Sigma Securities's portfolio in Q2 2026, its #1602 holding.
Two Sigma Securities first reported a position in Mereo BioPharma in Q4 2021 and has held it in 6 quarters since.
Two Sigma Securities's Mereo BioPharma position peaked at $107K in Q2 2022.
60 funds tracked by Wall St. Rank held Mereo BioPharma as of Q2 2026.

Based on Two Sigma Securities's 13F filing for Q2 2026, filed 14 Aug 2026.