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Two Sigma Investments

Two Sigma Investments Portfolio holdings

AUM $124B
1-Year Est. Return 33.93%
This Fund
S&P 500
This Quarter Est. Return
+14.35%
1 Year Est. Return
+33.93%
3 Year Est. Return
+96.56%
5 Year Est. Return
+105.93%
10 Year Est. Return
+538.88%
AUM
$56.5B
AUM Growth
+$9.69B
Cap. Flow
+$2.96B
Cap. Flow %
5.25%
Top 10 Hldgs %
7.66%
Holding
3,681
New
509
Increased
1,200
Reduced
1,275
Closed
531

Top Buys

Rank Stock Value
1
IGV icon
iShares Expanded Tech-Software Sector ETF
IGV
+$312M
2
UNH icon
UnitedHealth
UNH
+$286M
3
DUOL icon
Duolingo
DUOL
+$247M
4
AON icon
Aon
AON
+$226M
5
CB icon
Chubb
CB
+$221M

Sector Composition

Rank Sector Weight
1 Technology 16.79%
2 Financials 14.45%
3 Healthcare 12.9%
4 Consumer Discretionary 8.96%
5 Industrials 8.83%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake
Capital Flow
TSHA icon
2951
Taysha Gene Therapies
TSHA
$1.88B
$75.5K ﹤0.01%
+32,682
New +$71K
KYNB
2952
Kyntra Bio
KYNB
$29.6M
$74.8K ﹤0.01%
14,111
-9,267
-40% -$67.6K
RGP icon
2953
Resources Connection
RGP
$145M
$74.8K ﹤0.01%
13,921
-43,427
-76% -$236K
TEAD
2954
Teads Holding Co
TEAD
$66.9M
$74K ﹤0.01%
+29,822
New +$90.2K
GNLX icon
2955
Genelux
GNLX
$119M
$71.7K ﹤0.01%
24,992
-6,300
-20% -$16.6K
PEPG icon
2956
PepGen
PEPG
$197M
$70.8K ﹤0.01%
63,740
+17,546
+38% +$24.8K
AIRS icon
2957
AirSculpt Technologies
AIRS
$354M
$70.2K ﹤0.01%
+14,541
New +$49.4K
DTIL icon
2958
Precision BioSciences
DTIL
$207M
$68.7K ﹤0.01%
16,363
+2,798
+21% +$13.8K
AUID icon
2959
authID Inc
AUID
$10.5M
$68.4K ﹤0.01%
+12,926
New +$75.7K
LPL icon
2960
LG Display
LPL
$3.3B
$67.4K ﹤0.01%
+19,713
New +$60.9K
ALTO icon
2961
Alto Ingredients
ALTO
$339M
$67.4K ﹤0.01%
58,595
-87,085
-60% -$83.4K
TPIC
2962
DELISTED
TPI Composites
TPIC
$65.7K ﹤0.01%
76,438
-1,083
-1% -$1.1K
ATNM icon
2963
Actinium Pharmaceuticals
ATNM
$25.1M
$65.2K ﹤0.01%
+46,545
New +$69.7K
BTCS icon
2964
BTCS Inc
BTCS
$55.3M
$65.1K ﹤0.01%
+29,608
New +$62.8K
ACB
2965
Aurora Cannabis
ACB
$184M
$64.9K ﹤0.01%
15,307
+209
+1% +$1.01K
FTCI icon
2966
FTC Solar
FTCI
$45.4M
$64.7K ﹤0.01%
14,285
SND icon
2967
Smart Sand
SND
$195M
$64.3K ﹤0.01%
32,013
-409
-1% -$828
AVTX icon
2968
Avalo Therapeutics
AVTX
$984M
$64.3K ﹤0.01%
+12,889
New +$60.2K
EGAN icon
2969
eGain
EGAN
$201M
$63.3K ﹤0.01%
10,135
-17,291
-63% -$92.5K
TTI icon
2970
TETRA Technologies
TTI
$1.26B
$63.1K ﹤0.01%
+18,766
New +$54.6K
IMRX icon
2971
Immuneering
IMRX
$292M
$62.5K ﹤0.01%
18,553
-17,204
-48% -$29.5K
ACIU icon
2972
AC Immune
ACIU
$239M
$62.3K ﹤0.01%
+30,690
New +$53.4K
OKUR
2973
OnKure Therapeutics
OKUR
$167M
$61.8K ﹤0.01%
25,862
-1,286
-5% -$3.37K
STTK icon
2974
Shattuck Labs
STTK
$692M
$60.9K ﹤0.01%
76,934
-8,304
-10% -$8.05K
NNDM
2975
Nano Dimension
NNDM
$345M
$60.9K ﹤0.01%
37,596
+9,954
+36% +$15.2K

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Two Sigma Investments's Q2 2025 Portfolio in Review

As of Q2 2025, Two Sigma Investments held 3,681 positions worth $56.5B, up 21% from $46.8B the previous quarter. Its ten largest holdings account for 7.7% of the portfolio.

Two Sigma Investments deployed $2.96B of net new capital in Q2 2025, opening 509 new positions and adding to 1,200 existing holdings. Its largest new stake was iShares Expanded Tech-Software Sector ETF: 3,154,300 shares worth $345M.

By sector, the portfolio is most concentrated in Technology at 17% of assets, down from 18% a quarter earlier, followed by Financials and Healthcare.

On the sell side, the largest reduction was Broadcom, an estimated $338M trimmed.

  • Two Sigma Investments's largest Q2 2025 buy was iShares Expanded Tech-Software Sector ETF: 3,154,300 shares worth $345M.
  • Two Sigma Investments added most to UnitedHealth in Q2 2025, an estimated $286M increase.
  • Two Sigma Investments's biggest Q2 2025 reduction was Broadcom, cutting an estimated $338M.
  • Two Sigma Investments fully exited State Street Utilities Select Sector SPDR ETF in Q2 2025, selling an estimated $134M.
  • Two Sigma Investments's ten largest holdings make up 7.7% of its $56.5B portfolio in Q2 2025.
  • Two Sigma Investments opened 509 new positions and closed 531 in Q2 2025.
  • Two Sigma Investments's portfolio value rose 21% quarter-over-quarter to $56.5B.

Based on Two Sigma Investments's 13F filing for Q2 2025, filed 14 Aug 2025.