Two Sigma Investments
OKUR

Two Sigma Investments’s OnKure Therapeutics OKUR Stock Holding History

Two Sigma Investments’s Portfolio OKUR Stock Details OKUR Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$100K Buy
24,262
+12,942
+114% +$40K ﹤0.01% 4386
2025
Q4 		$32.8K Sell
11,320
-14,115
-55% -$42.3K ﹤0.01% 3969
2025
Q3 		$69.9K Sell
25,435
-427
-2% -$1.06K ﹤0.01% 3510
2025
Q2 		$61.8K Sell
25,862
-1,286
-5% -$3.37K ﹤0.01% 3051
2025
Q1 		$117K Buy
+27,148
New +$153K ﹤0.01% 2947
2024
Q4 		– Sell
-13,533
Closed -$230K – 3552
2024
Q3 		$230K Buy
13,533
+2,347
+21% +$34.7K ﹤0.01% 2766
2024
Q2 		$169K Sell
11,186
-1,873
-14% -$31.8K ﹤0.01% 2762
2024
Q1 		$217K Sell
13,059
-5,188
-28% -$85.6K ﹤0.01% 2685
2023
Q4 		$292K Buy
+18,247
New +$1.14M ﹤0.01% 2708

Other funds holding OKUR

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
ACA
Acorn Capital Advisors New York $352M AUM 299.18% 1-Year Est. Return
SG
StepStone Group La Jolla, California $207M AUM 12.33% 1-Year Est. Return
ACM
ADAR1 Capital Management Austin, Texas $1.7B AUM 340.85% 1-Year Est. Return
PM
Prosight Management Dallas, Texas $610M AUM 40.86% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
VC
Vivo Capital Palo Alto, California $1.2B AUM 911.44% 1-Year Est. Return
VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return
FCMV
Foresite Capital Management VI Larkspur, California $460M AUM 261.77% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return

Two Sigma Investments's OKUR Position: Q1 2026 in Review

Two Sigma Investments increased its OnKure Therapeutics (OKUR) stake by 114% in Q1 2026, buying an estimated $40K and bringing the position to 24,262 shares worth $100K. The position accounts for ﹤0.01% of the portfolio, ranked #4386.

Two Sigma Investments first reported a position in OKUR in Q4 2023 and has held it in 9 quarters since. The position peaked at $292K in Q4 2023. 51 funds tracked by Wall St. Rank hold OKUR as of Q1 2026.

  • Two Sigma Investments held 24,262 shares of OnKure Therapeutics worth $100K as of Q1 2026.
  • Two Sigma Investments bought 12,942 OnKure Therapeutics shares in Q1 2026, an estimated $40K.
  • OnKure Therapeutics made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #4386 holding.
  • Two Sigma Investments first reported a position in OnKure Therapeutics in Q4 2023 and has held it in 9 quarters since.
  • Two Sigma Investments's OnKure Therapeutics position peaked at $292K in Q4 2023.
  • 51 funds tracked by Wall St. Rank held OnKure Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.