Two Sigma Investments
REPL icon

Two Sigma Investments’s Replimune Group REPL Stock Holding History

Two Sigma Investments’s Portfolio REPL Stock Details REPL Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$2.64M Sell
344,751
-99,323
-22% -$759K ﹤0.01% 2554
2025
Q4 		$4.32M Buy
444,074
+286,575
+182% +$2.44M 0.01% 1845
2025
Q3 		$660K Buy
157,499
+135,078
+602% +$863K ﹤0.01% 2849
2025
Q2 		$208K Sell
22,421
-21,982
-50% -$192K ﹤0.01% 2904
2025
Q1 		$433K Sell
44,403
-168,183
-79% -$2.08M ﹤0.01% 2581
2024
Q4 		$2.57M Buy
212,586
+33,346
+19% +$405K 0.01% 1547
2024
Q3 		$1.96M Sell
179,240
-27,780
-13% -$282K ﹤0.01% 1695
2024
Q2 		$1.86M Sell
207,020
-101,821
-33% -$710K ﹤0.01% 1600
2024
Q1 		$2.52M Buy
308,841
+194,659
+170% +$1.6M 0.01% 1327
2023
Q4 		$963K Buy
+114,182
New +$1.32M ﹤0.01% 2105
2023
Q3 		– Sell
-182,111
Closed -$4.23M – 3170
2023
Q2 		$4.23M Sell
182,111
-72,813
-29% -$1.42M 0.01% 1002
2023
Q1 		$4.5M Buy
+254,924
New +$6.06M 0.01% 960
2022
Q4 		– Sell
-84,634
Closed -$1.46M – 3030
2022
Q3 		$1.46M Buy
84,634
+24,427
+41% +$466K 0.01% 1295
2022
Q2 		$1.05M Sell
60,207
-158,585
-72% -$2.61M ﹤0.01% 1524
2022
Q1 		$3.71M Buy
218,792
+122,084
+126% +$2.3M 0.01% 1066
2021
Q4 		$2.62M Sell
96,708
-9,448
-9% -$283K 0.01% 1684
2021
Q3 		$3.15M Sell
106,156
-50,732
-32% -$1.65M 0.01% 1574
2021
Q2 		$6.03M Sell
156,888
-211,807
-57% -$7.24M 0.01% 1094
2021
Q1 		$11.2M Buy
368,695
+39,763
+12% +$1.49M 0.03% 658
2020
Q4 		$12.5M Buy
328,932
+265,097
+415% +$11M 0.04% 520
2020
Q3 		$1.47M Buy
63,835
+51,008
+398% +$1.16M 0.01% 1500
2020
Q2 		$319K Buy
+12,827
New +$227K ﹤0.01% 2333
2020
Q1 		– Sell
-34,332
Closed -$493K – 3710
2019
Q4 		$493K Buy
+34,332
New +$495K ﹤0.01% 2812

Other funds holding REPL

BBA
Baker Bros. Advisors New York $17.4B AUM 131.5% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return
RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
SCM
Suvretta Capital Management New York $3.92B AUM 86.67% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
FIS
FCPM III Services Naarden, Netherlands $722M AUM 73.61% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
D.E. Shaw & Co
D.E. Shaw & Co New York $166B AUM 43.98% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return

Two Sigma Investments's REPL Position: Q1 2026 in Review

Two Sigma Investments reduced its Replimune Group (REPL) stake by 22% in Q1 2026, selling an estimated $759K and leaving 344,751 shares worth $2.64M. The position accounts for ﹤0.01% of the portfolio, ranked #2554.

Two Sigma Investments first reported a position in REPL in Q4 2019 and has held it in 23 quarters since. The position peaked at $12.5M in Q4 2020. 180 funds tracked by Wall St. Rank hold REPL as of Q1 2026.

  • Two Sigma Investments held 344,751 shares of Replimune Group worth $2.64M as of Q1 2026.
  • Two Sigma Investments sold 99,323 Replimune Group shares in Q1 2026, an estimated $759K.
  • Replimune Group made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #2554 holding.
  • Two Sigma Investments first reported a position in Replimune Group in Q4 2019 and has held it in 23 quarters since.
  • Two Sigma Investments's Replimune Group position peaked at $12.5M in Q4 2020.
  • 180 funds tracked by Wall St. Rank held Replimune Group as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.