Replimune Group
REPL
164 hedge funds and large institutions have $775M invested in Replimune Group in 2025 Q4 according to their latest regulatory filings, with 36 funds opening new positions, 58 increasing their positions, 51 reducing their positions, and 33 closing their positions.
435% more call options, than puts
Call options by funds: $46.9M | Put options by funds: $8.77M
123% more capital invested
Capital invested by funds: $348M → $775M (+$428M)
100% more funds holding in top 10
Funds holding in top 10: 1 → 2 (+1)
14% more repeat investments, than reductions
Existing positions increased: 58 | Existing positions reduced: 51
9% more first-time investments, than exits
New positions opened: 36 | Existing positions closed: 33
1% more funds holding
Funds holding: 163 → 164 (+1)
4.52% less ownership
Funds ownership: 106.18% → 101.66% (-4.5%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
D.E. Shaw & Co
New York
|
+$18.5M |
| 2 |
Adage Capital Partners
Boston,
Massachusetts
|
+$15.4M |
| 3 |
Fidelity Investments
Boston,
Massachusetts
|
+$13.8M |
| 4 |
CC
Commodore Capital
New York
|
+$12.1M |
| 5 |
RA
Rosalind Advisors
Toronto,
Ontario, Canada
|
+$12M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Point72 Asset Management
Stamford,
Connecticut
|
-$30.2M |
| 2 |
Balyasny Asset Management
Chicago,
Illinois
|
-$22.1M |
| 3 |
TCM
Tang Capital Management
San Diego,
California
|
-$14.2M |
| 4 |
B
Braidwell
Stamford,
Connecticut
|
-$11.5M |
| 5 |
FIS
FCPM III Services
Naarden,
Netherlands
|
-$11.5M |
REPL Hedge Fund Activity: Q4 2025 in Review
164 of the 8,270 institutional investors tracked by Wall St. Rank reported a position in Replimune Group (REPL) for Q4 2025, worth a combined $775M — up 123% from $348M a quarter earlier.
Buyers outnumbered sellers: 36 funds opened new REPL positions and 33 closed out — a net gain of 3 holders — while 58 added to existing stakes and 51 trimmed.
The largest buyer was D.E. Shaw & Co, adding an estimated $18.5M. The largest seller was Point72 Asset Management, cutting an estimated $30.2M.
- 164 institutional investors held Replimune Group (REPL) as of Q4 2025, up from 163 in Q3 2025.
- Funds reported $775M of Replimune Group stock for Q4 2025, up 123% quarter-over-quarter.
- 36 funds opened new Replimune Group positions in Q4 2025 and 33 closed out, a net change of +3 holders.
- The largest Replimune Group buyer in Q4 2025 was D.E. Shaw & Co, an estimated $18.5M added.
- The largest Replimune Group seller in Q4 2025 was Point72 Asset Management, an estimated $30.2M sold.
Based on aggregated 13F filings for Q4 2025.