Two Sigma Investments
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Two Sigma Investments’s Werewolf Therapeutics HOWL Stock Holding History

Two Sigma Investments’s Portfolio HOWL Stock Details HOWL Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-20,139
Closed -$39.7K – 4208
2025
Q3 		$39.7K Sell
20,139
-25,283
-56% -$34.6K ﹤0.01% 3556
2025
Q2 		$49.5K Sell
45,422
-12,710
-22% -$13.1K ﹤0.01% 3062
2025
Q1 		$56.5K Sell
58,132
-35,308
-38% -$46.2K ﹤0.01% 3032
2024
Q4 		$138K Sell
93,440
-87,168
-48% -$178K ﹤0.01% 2930
2024
Q3 		$383K Sell
180,608
-38,758
-18% -$88.2K ﹤0.01% 2580
2024
Q2 		$535K Buy
219,366
+34,307
+19% +$165K ﹤0.01% 2338
2024
Q1 		$1.2M Buy
185,059
+38,323
+26% +$223K ﹤0.01% 1840
2023
Q4 		$566K Buy
+146,736
New +$375K ﹤0.01% 2396
2023
Q3 		– Sell
-16,537
Closed -$50.4K – 3059
2023
Q2 		$50.4K Sell
16,537
-9,300
-36% -$26.2K ﹤0.01% 2829
2023
Q1 		$67.2K Sell
25,837
-1,348
-5% -$4.02K ﹤0.01% 2717
2022
Q4 		$55.7K Buy
+27,185
New +$71.1K ﹤0.01% 2578
2022
Q2 		– Sell
-15,180
Closed -$67K – 2699
2022
Q1 		$67K Sell
15,180
-6,854
-31% -$48K ﹤0.01% 2468
2021
Q4 		$262K Buy
+22,034
New +$333K ﹤0.01% 3738

Other funds holding HOWL

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
MB
MPM BioImpact Boston, Massachusetts $1.29B AUM 141.72% 1-Year Est. Return
Bank of America
Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
LCM
Lynx1 Capital Management San Juan, Puerto Rico $633M AUM 173.22% 1-Year Est. Return
SFM
Sphera Funds Management Tel Aviv, Israel $630M AUM 108.65% 1-Year Est. Return
DF
DC Funds Mclean, Virginia $1.49M AUM 18.57% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Two Sigma Investments's HOWL Position: Q4 2025 in Review

Two Sigma Investments sold out of Werewolf Therapeutics (HOWL) in Q4 2025, closing a stake of 20,139 shares — an estimated $39.7K sold.

Two Sigma Investments first reported a position in HOWL in Q4 2021 and held it in 13 quarters. The position peaked at $1.2M in Q1 2024. 51 funds tracked by Wall St. Rank hold HOWL as of Q4 2025.

  • Two Sigma Investments reported no remaining Werewolf Therapeutics position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Investments sold 20,139 Werewolf Therapeutics shares in Q4 2025, an estimated $39.7K.
  • Two Sigma Investments first reported a position in Werewolf Therapeutics in Q4 2021 and held it in 13 quarters.
  • Two Sigma Investments's Werewolf Therapeutics position peaked at $1.2M in Q1 2024.
  • 51 funds tracked by Wall St. Rank held Werewolf Therapeutics as of Q4 2025.

Based on Two Sigma Investments's 13F filing for Q4 2025, filed 17 Feb 2026.