Two Sigma Investments
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Two Sigma Investments’s Enanta Pharmaceuticals ENTA Stock Holding History

Two Sigma Investments’s Portfolio ENTA Stock Details ENTA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$3.38M Sell
267,364
-18,084
-6% -$242K ﹤0.01% 2342
2025
Q4 		$4.5M Buy
285,448
+224,726
+370% +$2.85M 0.01% 1809
2025
Q3 		$727K Sell
60,722
-17,733
-23% -$142K ﹤0.01% 2789
2025
Q2 		$593K Buy
78,455
+565
+0.7% +$3.4K ﹤0.01% 2510
2025
Q1 		$430K Buy
77,890
+13,607
+21% +$84K ﹤0.01% 2583
2024
Q4 		$370K Sell
64,283
-126,974
-66% -$1.22M ﹤0.01% 2665
2024
Q3 		$1.98M Buy
191,257
+6,700
+4% +$87.6K ﹤0.01% 1687
2024
Q2 		$2.39M Sell
184,557
-72,752
-28% -$982K 0.01% 1430
2024
Q1 		$4.49M Sell
257,309
-74,923
-23% -$991K 0.01% 1025
2023
Q4 		$3.13M Buy
332,232
+120,263
+57% +$1.12M 0.01% 1234
2023
Q3 		$2.37M Buy
211,969
+182,346
+616% +$2.94M 0.01% 1278
2023
Q2 		$634K Buy
+29,623
New +$873K ﹤0.01% 2214
2023
Q1 		– Sell
-32,114
Closed -$1.49M – 3018
2022
Q4 		$1.49M Buy
32,114
+17,922
+126% +$817K ﹤0.01% 1485
2022
Q3 		$736K Buy
14,192
+601
+4% +$35.1K ﹤0.01% 1597
2022
Q2 		$642K Buy
+13,591
New +$738K ﹤0.01% 1721
2022
Q1 		– Sell
-82,682
Closed -$6.18M – 3162
2021
Q4 		$6.18M Buy
82,682
+17,904
+28% +$1.41M 0.01% 1070
2021
Q3 		$3.68M Sell
64,778
-899
-1% -$44.4K 0.01% 1464
2021
Q2 		$2.89M Buy
65,677
+1,267
+2% +$62K 0.01% 1579
2021
Q1 		$3.18M Sell
64,410
-829
-1% -$41.4K 0.01% 1353
2020
Q4 		$2.75M Buy
65,239
+18,285
+39% +$804K 0.01% 1287
2020
Q3 		$2.15M Sell
46,954
-19,794
-30% -$959K 0.01% 1252
2020
Q2 		$3.35M Sell
66,748
-35,986
-35% -$1.86M 0.02% 840
2020
Q1 		$5.28M Sell
102,734
-32,021
-24% -$1.71M 0.04% 476
2019
Q4 		$8.32M Buy
134,755
+66,198
+97% +$4.1M 0.03% 704
2019
Q3 		$4.12M Buy
68,557
+9,511
+16% +$707K 0.01% 966
2019
Q2 		$4.98M Buy
59,046
+31,150
+112% +$2.8M 0.02% 901
2019
Q1 		$2.67M Sell
27,896
-32,971
-54% -$2.96M 0.01% 1259
2018
Q4 		$4.31M Buy
60,867
+37,352
+159% +$2.86M 0.02% 869
2018
Q3 		$2.01M Sell
23,515
-66,657
-74% -$6.68M 0.01% 1482
2018
Q2 		$10.5M Buy
90,172
+35,877
+66% +$3.58M 0.03% 651
2018
Q1 		$4.39M Sell
54,295
-4,660
-8% -$359K 0.01% 1026
2017
Q4 		$3.46M Buy
58,955
+45,002
+323% +$2.25M 0.01% 1087
2017
Q3 		$653K Sell
13,953
-31,923
-70% -$1.28M ﹤0.01% 1982
2017
Q2 		$1.65M Buy
45,876
+28,403
+163% +$908K 0.01% 1558
2017
Q1 		$538K Sell
17,473
-77,723
-82% -$2.42M ﹤0.01% 2298
2016
Q4 		$3.19M Buy
95,196
+27,848
+41% +$798K 0.01% 1142
2016
Q3 		$1.79M Buy
+67,348
New +$1.56M 0.01% 1547
2014
Q4 		– Sell
-24,512
Closed -$970K – 2256
2014
Q3 		$970K Buy
24,512
+8,013
+49% +$319K ﹤0.01% 1067
2014
Q2 		$711K Buy
+16,499
New +$629K ﹤0.01% 1456
2014
Q1 		– Sell
-49,148
Closed -$1.34M – 2057
2013
Q4 		$1.34M Buy
+49,148
New +$1.19M 0.01% 1192

Other funds holding ENTA

Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
FCM
Farallon Capital Management San Francisco, California $17.5B AUM 50.95% 1-Year Est. Return
KAM
Krensavage Asset Management New York $256M AUM 69.63% 1-Year Est. Return
DTC
Deep Track Capital Greenwich, Connecticut $6.12B AUM 144% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
SSC
Spruce Street Capital New York $416M AUM
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return
Acadian Asset Management
Acadian Asset Management Boston, Massachusetts $70.5B AUM 36% 1-Year Est. Return

Two Sigma Investments's ENTA Position: Q1 2026 in Review

Two Sigma Investments reduced its Enanta Pharmaceuticals (ENTA) stake by 6.3% in Q1 2026, selling an estimated $242K and leaving 267,364 shares worth $3.38M. The position accounts for ﹤0.01% of the portfolio, ranked #2342.

Two Sigma Investments first reported a position in ENTA in Q4 2013 and has held it in 40 quarters since. The position peaked at $10.5M in Q2 2018. 132 funds tracked by Wall St. Rank hold ENTA as of Q1 2026.

  • Two Sigma Investments held 267,364 shares of Enanta Pharmaceuticals worth $3.38M as of Q1 2026.
  • Two Sigma Investments sold 18,084 Enanta Pharmaceuticals shares in Q1 2026, an estimated $242K.
  • Enanta Pharmaceuticals made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #2342 holding.
  • Two Sigma Investments first reported a position in Enanta Pharmaceuticals in Q4 2013 and has held it in 40 quarters since.
  • Two Sigma Investments's Enanta Pharmaceuticals position peaked at $10.5M in Q2 2018.
  • 132 funds tracked by Wall St. Rank held Enanta Pharmaceuticals as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.