Two Sigma Investments
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Two Sigma Investments’s Biomea Fusion BMEA Stock Holding History

Two Sigma Investments’s Portfolio BMEA Stock Details BMEA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$595K Sell
388,696
-34,773
-8% -$45.7K ﹤0.01% 3620
2025
Q4 		$525K Sell
423,469
-139,499
-25% -$195K ﹤0.01% 3279
2025
Q3 		$1.14M Buy
562,968
+213,321
+61% +$391K ﹤0.01% 2494
2025
Q2 		$629K Sell
349,647
-122,712
-26% -$236K ﹤0.01% 2479
2025
Q1 		$1.01M Sell
472,359
-87,571
-16% -$298K ﹤0.01% 2171
2024
Q4 		$2.17M Buy
559,930
+286,049
+104% +$2.28M ﹤0.01% 1654
2024
Q3 		$2.77M Sell
273,881
-56,793
-17% -$369K 0.01% 1474
2024
Q2 		$1.49M Buy
330,674
+297,273
+890% +$3.02M ﹤0.01% 1755
2024
Q1 		$499K Sell
33,401
-104,837
-76% -$1.73M ﹤0.01% 2335
2023
Q4 		$2.01M Sell
138,238
-278,854
-67% -$3.39M ﹤0.01% 1546
2023
Q3 		$5.74M Buy
417,092
+331,097
+385% +$5.97M 0.02% 827
2023
Q2 		$1.89M Buy
85,995
+66,079
+332% +$2.07M ﹤0.01% 1472
2023
Q1 		$618K Buy
19,916
+3,792
+24% +$47.1K ﹤0.01% 2109
2022
Q4 		$136K Buy
+16,124
New +$138K ﹤0.01% 2463
2022
Q1 		– Sell
-17,010
Closed -$127K – 2816
2021
Q4 		$127K Buy
+17,010
New +$180K ﹤0.01% 4017

Other funds holding BMEA

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
ACM
Aisling Capital Management New York $476M AUM 128.63% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
Marshall Wace
Marshall Wace London, United Kingdom $100B AUM 35.1% 1-Year Est. Return
Citadel Advisors
Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return
Mariner
Mariner Overland Park, Kansas $85.7B AUM 24.21% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Susquehanna International Group
Susquehanna International Group Bala Cynwyd, Pennsylvania $893B AUM 36.07% 1-Year Est. Return
FISPB
Fideuram - Intesa Sanpaolo Private Banking Turin $2.85B AUM

Two Sigma Investments's BMEA Position: Q1 2026 in Review

Two Sigma Investments reduced its Biomea Fusion (BMEA) stake by 8.2% in Q1 2026, selling an estimated $45.7K and leaving 388,696 shares worth $595K. The position accounts for ﹤0.01% of the portfolio, ranked #3620.

Two Sigma Investments first reported a position in BMEA in Q4 2021 and has held it in 15 quarters since. The position peaked at $5.74M in Q3 2023. 65 funds tracked by Wall St. Rank hold BMEA as of Q1 2026.

  • Two Sigma Investments held 388,696 shares of Biomea Fusion worth $595K as of Q1 2026.
  • Two Sigma Investments sold 34,773 Biomea Fusion shares in Q1 2026, an estimated $45.7K.
  • Biomea Fusion made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #3620 holding.
  • Two Sigma Investments first reported a position in Biomea Fusion in Q4 2021 and has held it in 15 quarters since.
  • Two Sigma Investments's Biomea Fusion position peaked at $5.74M in Q3 2023.
  • 65 funds tracked by Wall St. Rank held Biomea Fusion as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.