Two Sigma Investments
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Two Sigma Investments’s ALX Oncology ALXO Stock Holding History

Two Sigma Investments’s Portfolio ALXO Stock Details ALXO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$3.18M Buy
1,587,833
+947,628
+148% +$1.81M ﹤0.01% 2395
2025
Q4 		$723K Buy
640,205
+33,534
+6% +$50.8K ﹤0.01% 3117
2025
Q3 		$1.11M Buy
606,671
+128,737
+27% +$111K ﹤0.01% 2508
2025
Q2 		$198K Sell
477,934
-64,721
-12% -$32.7K ﹤0.01% 2917
2025
Q1 		$338K Sell
542,655
-161,476
-23% -$194K ﹤0.01% 2668
2024
Q4 		$1.18M Buy
704,131
+44,072
+7% +$67.7K ﹤0.01% 2076
2024
Q3 		$1.2M Buy
660,059
+367,833
+126% +$1.37M ﹤0.01% 2018
2024
Q2 		$1.76M Buy
292,226
+226,771
+346% +$2.79M ﹤0.01% 1633
2024
Q1 		$730K Sell
65,455
-466
-0.7% -$6.54K ﹤0.01% 2141
2023
Q4 		$982K Buy
+65,921
New +$625K ﹤0.01% 2092
2023
Q2 		– Sell
-108,351
Closed -$490K – 2988
2023
Q1 		$490K Buy
108,351
+62,351
+136% +$472K ﹤0.01% 2217
2022
Q4 		$518K Sell
46,000
-60,652
-57% -$681K ﹤0.01% 2001
2022
Q3 		$1.02M Sell
106,652
-137,820
-56% -$1.61M ﹤0.01% 1465
2022
Q2 		$1.98M Buy
244,472
+97,377
+66% +$1.06M 0.01% 1212
2022
Q1 		$2.49M Sell
147,095
-242,107
-62% -$4.13M 0.01% 1246
2021
Q4 		$8.36M Buy
389,202
+386,302
+13,321% +$16.7M 0.02% 885
2021
Q3 		$214K Buy
+2,900
New +$193K ﹤0.01% 3918

Other funds holding ALXO

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TCM
TCG Crossover Management Palo Alto, California $3.5B AUM 1,165.83% 1-Year Est. Return
VP
venBio Partners San Francisco, California $281M AUM 261.03% 1-Year Est. Return
RG
Redmile Group San Francisco, California $1.51B AUM 164.17% 1-Year Est. Return
Blackstone Inc
Blackstone Inc New York $25.6B AUM 26.83% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Marshall Wace
Marshall Wace London, United Kingdom $100B AUM 35.1% 1-Year Est. Return
VC
Vivo Capital Palo Alto, California $1.2B AUM 911.44% 1-Year Est. Return
AC
Almitas Capital Santa Monica, California $443M AUM 42.36% 1-Year Est. Return

Two Sigma Investments's ALXO Position: Q1 2026 in Review

Two Sigma Investments increased its ALX Oncology (ALXO) stake by 148% in Q1 2026, buying an estimated $1.81M and bringing the position to 1,587,833 shares worth $3.18M. The position accounts for ﹤0.01% of the portfolio, ranked #2395.

Two Sigma Investments first reported a position in ALXO in Q3 2021 and has held it in 17 quarters since. The position peaked at $8.36M in Q4 2021. 69 funds tracked by Wall St. Rank hold ALXO as of Q1 2026.

  • Two Sigma Investments held 1,587,833 shares of ALX Oncology worth $3.18M as of Q1 2026.
  • Two Sigma Investments bought 947,628 ALX Oncology shares in Q1 2026, an estimated $1.81M.
  • ALX Oncology made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #2395 holding.
  • Two Sigma Investments first reported a position in ALX Oncology in Q3 2021 and has held it in 17 quarters since.
  • Two Sigma Investments's ALX Oncology position peaked at $8.36M in Q4 2021.
  • 69 funds tracked by Wall St. Rank held ALX Oncology as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.