ALXO icon

ALX Oncology

1.06 USD
-0.12
10.17%
At close Updated Sep 12, 4:00 PM EDT
Pre-market
After hours
1.05
-0.01
0.94%
1 day
-10.17%
5 days
-13.11%
1 month
72.33%
3 months
96.04%
6 months
10.49%
Year to date
-32.05%
1 year
-50.47%
5 years
-97.3%
10 years
-96.47%
 

About: ALX Oncology Holdings Inc is a clinical-stage immuno-oncology company focused on helping patients fight cancer by developing a pipeline of product candidates based on expertise in protein engineering and oncology led by the CD47 blocker, evorpacept, currently in phase 1 and 2 clinical trials. Cancer cells leverage CD47, a cell surface protein, as a don't eat me signal to evade detection by the immune system. The company is developing a next-generation checkpoint inhibitor designed to have a high affinity for CD47 and to avoid the limitations caused by hematologic toxicities inherent in other CD47 blocking approaches.

Employees: 49

0
Funds holding %
of 7,462 funds
Analysts bullish %

Fund manager confidence

Based on 2025 Q2 regulatory disclosures by fund managers ($100M+ AUM)

586% more call options, than puts

Call options by funds: $48K | Put options by funds: $7K

0% more funds holding in top 10

Funds holding in top 10: 1 [Q1] → 1 (+0) [Q2]

10.75% less ownership

Funds ownership: 65.2% [Q1] → 54.45% (-10.75%) [Q2]

28% less funds holding

Funds holding: 85 [Q1] → 61 (-24) [Q2]

43% less capital invested

Capital invested by funds: $22.1M [Q1] → $12.6M (-$9.55M) [Q2]

71% less first-time investments, than exits

New positions opened: 10 | Existing positions closed: 34

72% less repeat investments, than reductions

Existing positions increased: 9 | Existing positions reduced: 32

Financial journalist opinion

Based on 3 articles about ALXO published over the past 30 days

Neutral
GlobeNewsWire
2 days ago
ALX Oncology Appoints Board Member Barbara Klencke, M.D., as Interim Chief Medical Officer
SOUTH SAN FRANCISCO, Calif., Sept. 12, 2025 (GLOBE NEWSWIRE) -- ALX Oncology Holdings Inc., (“ALX Oncology” or “the Company”) (Nasdaq: ALXO), a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients' lives, today announced the appointment of Dr. Klencke to the role of Interim Chief Medical Officer (CMO) on a full-time basis. Dr. Alan Sandler is departing from the role of CMO and will return to his former position on the ALX Oncology Board of Directors (BOD), where he previously served.
ALX Oncology Appoints Board Member Barbara Klencke, M.D., as Interim Chief Medical Officer
Neutral
GlobeNewsWire
16 days ago
ALX Oncology to Participate in Upcoming Investor Conferences in September
SOUTH SAN FRANCISCO, Calif., Aug. 29, 2025 (GLOBE NEWSWIRE) -- ALX Oncology Holdings Inc., ("ALX Oncology" or the "Company") (Nasdaq: ALXO), a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients' lives, today announced that ALX Oncology leadership will participate in both the Cantor Global Healthcare Conference 2025 and H.C. Wainwright 27th Annual Global Investment Conference in New York.
ALX Oncology to Participate in Upcoming Investor Conferences in September
Neutral
GlobeNewsWire
26 days ago
ALX Oncology Doses First Patient in Phase 1 Dose Escalation Trial Evaluating ADC ALX2004 for the Treatment of EGFR-Expressing Solid Tumors
- A potential best- and first-in-class antibody-drug conjugate (ADC) for the treatment of EGFR-expressing solid tumors, ALX2004 is uniquely designed with every component optimized to maximize the therapeutic window -First-in-human trial of ALX2004 builds upon body of positive preclinical data demonstrating dose dependent anti-tumor activity and favorable safety profile -Initial safety data anticipated in first half 2026 SOUTH SAN FRANCISCO, Calif., Aug. 19, 2025 (GLOBE NEWSWIRE) -- ALX Oncology Holdings Inc., ("ALX Oncology" or the"Company") (Nasdaq: ALXO), a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients' lives, today announced that the first patient has been dosed in the Company's Phase 1 clinical trial for ALX2004, a potential best- and first-in-class, epidermal growth factor receptor (EGFR) ADC that is being studied for the treatment of EGFR-expressing solid tumors.
ALX Oncology Doses First Patient in Phase 1 Dose Escalation Trial Evaluating ADC ALX2004 for the Treatment of EGFR-Expressing Solid Tumors
Neutral
Seeking Alpha
1 month ago
ALX Oncology Holdings Inc. (ALXO) Q2 2025 Earnings Call Transcript
ALX Oncology Holdings Inc. (NASDAQ:ALXO ) Q2 2025 Earnings Conference Call August 12, 2023 4:30 AM ET Company Participants Alan Bart Sandler - Chief Medical Officer Harish Shantharam - Chief Financial Officer Jason W. Lettmann - CEO & Director Conference Call Participants Allison Marie Bratzel - Piper Sandler & Co., Research Division Li Wang Watsek - Cantor Fitzgerald & Co., Research Division Roger Song - Jefferies LLC, Research Division Samuel Evan Slutsky - LifeSci Capital, LLC, Research Division Ting Liu - UBS Investment Bank, Research Division Yu He - H.C.
ALX Oncology Holdings Inc. (ALXO) Q2 2025 Earnings Call Transcript
Neutral
GlobeNewsWire
1 month ago
ALX Oncology Reports Second Quarter 2025 Financial Results and Provides Corporate Update
– Data from ASPEN-06 trial highlights CD47 expression as a key predictive biomarker of greater response to evorpacept in HER2+ Gastric Cancer; updated data to be presented at a medical conference in Q4 2025
ALX Oncology Reports Second Quarter 2025 Financial Results and Provides Corporate Update
Neutral
GlobeNewsWire
1 month ago
ALX Oncology to Report Second Quarter 2025 Financial Results on August 12, 2025
SOUTH SAN FRANCISCO, Calif., Aug. 05, 2025 (GLOBE NEWSWIRE) -- ALX Oncology Holdings Inc., ("ALX Oncology" or the "Company") (Nasdaq: ALXO), a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients' lives, today announced plans to report its second quarter 2025 financial results and a business update on Tuesday, August 12th, 2025, after market close.
ALX Oncology to Report Second Quarter 2025 Financial Results on August 12, 2025
Neutral
GlobeNewsWire
3 months ago
ALX Oncology to Present at the Jefferies 2025 Global Healthcare Conference
SOUTH SAN FRANCISCO, Calif., May 30, 2025 (GLOBE NEWSWIRE) -- ALX Oncology Holdings Inc., ("ALX Oncology" or the "Company") (Nasdaq: ALXO), a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients' lives, today announced that management will participate in the Jefferies 2025 Global Healthcare Conference. Details are as follows:
ALX Oncology to Present at the Jefferies 2025 Global Healthcare Conference
Neutral
GlobeNewsWire
3 months ago
ALX Oncology Highlights Differentiated Design, Preclinical Data and Development Plans for EGFR-Targeted ADC, ALX2004, in R&D Webcast Event
- A potential best- and first-in-class antibody-drug conjugate (ADC) for the treatment of EGFR-expressing solid tumors, ALX2004 is uniquely designed with every component optimized to maximize the therapeutic window by reducing toxicity
ALX Oncology Highlights Differentiated Design, Preclinical Data and Development Plans for EGFR-Targeted ADC, ALX2004, in R&D Webcast Event
Neutral
GlobeNewsWire
4 months ago
ALX Oncology to Host R&D Webcast Event Highlighting its Novel EGFR Targeting Antibody-Drug Conjugate, ALX2004, on May 20, 2025
SOUTH SAN FRANCISCO, Calif., May 13, 2025 (GLOBE NEWSWIRE) -- ALX Oncology Holdings Inc., ("ALX Oncology" or the "Company") (Nasdaq: ALXO), a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients' lives, today announced that it will host a webcast event on May 20, 2025, to provide an update on ALX2004, the Company's potentially best- and first-in-class investigational antibody-drug conjugate (ADC). The webcast will highlight the novel mechanism of action, preclinical data and clinical development strategy for ALX2004 following clearance of the Investigational New Drug application from the U.S. Food and Drug Administration earlier this year.
ALX Oncology to Host R&D Webcast Event Highlighting its Novel EGFR Targeting Antibody-Drug Conjugate, ALX2004, on May 20, 2025
Neutral
GlobeNewsWire
4 months ago
ALX Oncology Reports First Quarter 2025 Financial Results and Provides Corporate Update
Following announcement of prioritized development strategy for evorpacept in combination with anti-cancer antibodies at R&D Day in March, Company is on track to initiate Phase 2 ASPEN-Breast and Phase 1 ASPEN-CRC studies in mid-2025 IND clearance received from U.S. FDA for novel EGFR-targeted antibody-drug conjugate (ADC), ALX2004, paving way for mid-year clinical program initiation; Company to host webcast focused on ALX2004 research program on May 20 Company will not pursue U.S. registrational path in gastric cancer following receipt of FDA feedback that accelerated approval pathway is not feasible based on ASPEN-06 due to standard-of-care evolving to ENHERTU® Data milestones expected across Company's three clinical programs in 2026 Cash runway has been extended into Q4 2026 SOUTH SAN FRANCISCO, Calif., May 08, 2025 (GLOBE NEWSWIRE) --  ALX Oncology Holdings Inc., (“ALX Oncology” or “the Company”) (Nasdaq: ALXO), a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients' lives, today reported financial results for the first quarter ended March 31, 2025, and provided a corporate update.
ALX Oncology Reports First Quarter 2025 Financial Results and Provides Corporate Update
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