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Two Sigma Advisers

Two Sigma Advisers Portfolio holdings

AUM $51.4B
1-Year Est. Return 31.07%
This Fund
S&P 500
This Quarter Est. Return
-3%
1 Year Est. Return
+31.07%
3 Year Est. Return
+128.94%
5 Year Est. Return
+161.75%
10 Year Est. Return
+607.04%
AUM
$44.4B
AUM Growth
+$1.2B
Cap. Flow
+$3.32B
Cap. Flow %
7.48%
Top 10 Hldgs %
17.65%
Holding
2,641
New
312
Increased
1,037
Reduced
994
Closed
281

Top Buys

Rank Stock Value
1
AVGO icon
Broadcom
AVGO
+$519M
2
CRM icon
Salesforce
CRM
+$460M
3
REGN icon
Regeneron Pharmaceuticals
REGN
+$381M
4
BSX icon
Boston Scientific
BSX
+$347M
5
ISRG icon
Intuitive Surgical
ISRG
+$319M

Top Sells

Rank Stock Value
1
V icon
Visa
V
+$555M
2
LLY icon
Eli Lilly
LLY
+$536M
3
META icon
Meta Platforms (Facebook)
META
+$433M
4
PGR icon
Progressive
PGR
+$330M
5
LRCX icon
Lam Research
LRCX
+$294M

Sector Composition

Rank Sector Weight
1 Technology 25.86%
2 Healthcare 15.38%
3 Financials 14.3%
4 Consumer Discretionary 11.43%
5 Industrials 10.56%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
GSM icon
2301
FerroAtlántica
GSM
$585M
$62.7K ﹤0.01%
16,900
-11,400
-40% -$44K
TEAD
2302
Teads Holding Co
TEAD
$77.4M
$62.7K ﹤0.01%
16,800
+4,100
+32% +$23.2K
ORIC icon
2303
Oric Pharmaceuticals
ORIC
$1.17B
$62.5K ﹤0.01%
11,200
-55,300
-83% -$484K
GPMT
2304
Granite Point Mortgage Trust
GPMT
$63.7M
$62.5K ﹤0.01%
24,025
-1,075
-4% -$3.06K
MIST icon
2305
Milestone Pharmaceuticals
MIST
$126M
$60.8K ﹤0.01%
+76,000
New +$151K
RLYB icon
2306
Rallybio
RLYB
$84.9M
$59.6K ﹤0.01%
11,378
-35
-0.3% -$221
ENIC icon
2307
Enel Chile
ENIC
$6.06B
$59.2K ﹤0.01%
18,100
-4,100
-18% -$13.1K
HIVE
2308
HIVE Digital Technologies
HIVE
$703M
$58.1K ﹤0.01%
40,100
-16,200
-29% -$39.9K
SRTS icon
2309
Sensus Healthcare
SRTS
$46.6M
$57.7K ﹤0.01%
12,200
+1,400
+13% +$8.15K
CMBM
2310
DELISTED
Cambium Networks
CMBM
$56.7K ﹤0.01%
80,300
-3,300
-4% -$3.23K
XBIT icon
2311
XBiotech
XBIT
$68.6M
$56.4K ﹤0.01%
+17,400
New +$60K
CMTG icon
2312
Claros Mortgage Trust
CMTG
$294M
$56.3K ﹤0.01%
+15,100
New +$51.8K
MTLS
2313
Materialise
MTLS
$366M
$56.1K ﹤0.01%
11,400
-4,400
-28% -$30.2K
DCGO icon
2314
DocGo
DCGO
$66.7M
$55.2K ﹤0.01%
20,900
-27,000
-56% -$108K
CRDF icon
2315
Cardiff Oncology
CRDF
$60.7M
$55K ﹤0.01%
17,500
+2,700
+18% +$10.7K
VRA icon
2316
Vera Bradley
VRA
$100M
$54.9K ﹤0.01%
24,400
-700
-3% -$2.26K
DSX icon
2317
Diana Shipping
DSX
$265M
$54.4K ﹤0.01%
34,892
-24,693
-41% -$44.8K
DXLG icon
2318
Destination XL Group
DXLG
$34.3M
$53.7K ﹤0.01%
36,800
-65,700
-64% -$154K
EGY icon
2319
Vaalco Energy
EGY
$553M
$51.7K ﹤0.01%
13,738
-3,000
-18% -$12.5K
ZH
2320
Zhihu
ZH
$287M
$51.1K ﹤0.01%
11,966
-1,000
-8% -$4.35K
SNDL icon
2321
Sundial Growers
SNDL
$318M
$50.1K ﹤0.01%
35,500
+9,400
+36% +$16K
ELEV
2322
DELISTED
Elevation Oncology
ELEV
$50K ﹤0.01%
193,100
+108,700
+129% +$62.1K
ARKO icon
2323
ARKO Corp
ARKO
$880M
$47.8K ﹤0.01%
12,100
-25,900
-68% -$151K
LYRA
2324
DELISTED
LYRA THERAPEUTICS INC
LYRA
$46K ﹤0.01%
7,290
-420
-5% -$3.93K
LONA
2325
LeonaBio Inc
LONA
$66.4M
$44.8K ﹤0.01%
15,710
-9,620
-38% -$42.6K
91 92
93
94 95

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Two Sigma Advisers's Q1 2025 Portfolio in Review

As of Q1 2025, Two Sigma Advisers held 2,641 positions worth $44.4B, up 2.8% from $43.2B the previous quarter. Its ten largest holdings account for 18% of the portfolio.

Two Sigma Advisers deployed $3.32B of net new capital in Q1 2025, opening 312 new positions and adding to 1,037 existing holdings. Its largest new stake was Regeneron Pharmaceuticals: 553,800 shares worth $351M.

By sector, the portfolio is most concentrated in Technology at 26% of assets, up from 25% a quarter earlier, followed by Healthcare and Financials.

On the sell side, the largest reduction was Visa, an estimated $555M trimmed.

  • Two Sigma Advisers's largest Q1 2025 buy was Regeneron Pharmaceuticals: 553,800 shares worth $351M.
  • Two Sigma Advisers added most to Broadcom in Q1 2025, an estimated $519M increase.
  • Two Sigma Advisers's biggest Q1 2025 reduction was Visa, cutting an estimated $555M.
  • Two Sigma Advisers fully exited Abbott in Q1 2025, selling an estimated $158M.
  • Two Sigma Advisers's ten largest holdings make up 18% of its $44.4B portfolio in Q1 2025.
  • Two Sigma Advisers opened 312 new positions and closed 281 in Q1 2025.
  • Two Sigma Advisers's portfolio value rose 2.8% quarter-over-quarter to $44.4B.

Based on Two Sigma Advisers's 13F filing for Q1 2025, filed 15 May 2025.