Two Sigma Advisers
LONA

Two Sigma Advisers’s LeonaBio Inc LONA Stock Holding History

Two Sigma Advisers’s Portfolio LONA Stock Details LONA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-14,860
Closed -$61.5K – 2351
2025
Q3 		$61.5K Sell
14,860
-560
-4% -$2.2K ﹤0.01% 2260
2025
Q2 		$46.6K Sell
15,420
-290
-2% -$821 ﹤0.01% 2260
2025
Q1 		$44.8K Sell
15,710
-9,620
-38% -$42.6K ﹤0.01% 2325
2024
Q4 		$149K Sell
25,330
-8,430
-25% -$47.6K ﹤0.01% 2167
2024
Q3 		$151K Sell
33,760
-2,330
-6% -$54.7K ﹤0.01% 2121
2024
Q2 		$956K Sell
36,090
-860
-2% -$20.3K ﹤0.01% 1572
2024
Q1 		$1.01M Buy
36,950
+7,090
+24% +$225K ﹤0.01% 1575
2023
Q4 		$726K Buy
29,860
+1,950
+7% +$34.6K ﹤0.01% 1775
2023
Q3 		$564K Sell
27,910
-3,540
-11% -$90.7K ﹤0.01% 1754
2023
Q2 		$928K Sell
31,450
-17,970
-36% -$512K ﹤0.01% 1569
2023
Q1 		$1.24M Buy
49,420
+16,210
+49% +$522K ﹤0.01% 1525
2022
Q4 		$1.05M Sell
33,210
-1,530
-4% -$48.2K ﹤0.01% 1542
2022
Q3 		$1.03M Buy
34,740
+24,180
+229% +$834K ﹤0.01% 1505
2022
Q2 		$322K Buy
10,560
+6,940
+192% +$636K ﹤0.01% 2091
2022
Q1 		$489K Sell
3,620
-960
-21% -$101K ﹤0.01% 1998
2021
Q4 		$597K Sell
4,580
-2,910
-39% -$368K ﹤0.01% 1831
2021
Q3 		$703K Buy
7,490
+3,940
+111% +$401K ﹤0.01% 1778
2021
Q2 		$364K Sell
3,550
-1,620
-31% -$283K ﹤0.01% 2071
2021
Q1 		$951K Sell
5,170
-570
-10% -$126K ﹤0.01% 1674
2020
Q4 		$1.97M Buy
+5,740
New +$1.35M 0.01% 1269

Other funds holding LONA

PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
ACA
Acorn Capital Advisors New York $366M AUM 474.6% 1-Year Est. Return
CC
Commodore Capital New York $1.68B AUM 375.52% 1-Year Est. Return
NMC
NEA Management Company Timonium, Maryland $1.59B AUM 234.06% 1-Year Est. Return
TCM
TCG Crossover Management Palo Alto, California $4.16B AUM 983.43% 1-Year Est. Return
KCM
Kalehua Capital Management Dallas, Texas $174M AUM
SSC
Spruce Street Capital New York $510M AUM
ACM
ADAR1 Capital Management Austin, Texas $2.19B AUM 374.99% 1-Year Est. Return
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return

Two Sigma Advisers's LONA Position: Q4 2025 in Review

Two Sigma Advisers sold out of LeonaBio Inc (LONA) in Q4 2025, closing a stake of 14,860 shares — an estimated $61.5K sold.

Two Sigma Advisers first reported a position in LONA in Q4 2020 and held it in 20 quarters. The position peaked at $1.97M in Q4 2020. 42 funds tracked by Wall St. Rank hold LONA as of Q4 2025.

  • Two Sigma Advisers reported no remaining LeonaBio Inc position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Advisers sold 14,860 LeonaBio Inc shares in Q4 2025, an estimated $61.5K.
  • Two Sigma Advisers first reported a position in LeonaBio Inc in Q4 2020 and held it in 20 quarters.
  • Two Sigma Advisers's LeonaBio Inc position peaked at $1.97M in Q4 2020.
  • 42 funds tracked by Wall St. Rank held LeonaBio Inc as of Q4 2025.

Based on Two Sigma Advisers's 13F filing for Q4 2025, filed 17 Feb 2026.