Two Sigma Advisers
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Two Sigma Advisers’s Ironwood Pharmaceuticals IRWD Stock Holding History

Two Sigma Advisers’s Portfolio IRWD Stock Details IRWD Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		– Sell
-3,140,100
Closed -$10.6M – 1064
2025
Q4 		$10.6M Sell
3,140,100
-176,400
-5% -$458K 0.02% 525
2025
Q3 		$4.34M Sell
3,316,500
-67,600
-2% -$70K 0.01% 797
2025
Q2 		$2.43M Buy
3,384,100
+1,499,500
+80% +$1.18M 0.01% 1024
2025
Q1 		$2.77M Buy
1,884,600
+650,600
+53% +$1.55M 0.01% 1029
2024
Q4 		$5.47M Sell
1,234,000
-26,500
-2% -$108K 0.01% 688
2024
Q3 		$5.19M Buy
1,260,500
+61,500
+5% +$331K 0.01% 696
2024
Q2 		$7.82M Sell
1,199,000
-86,000
-7% -$608K 0.02% 610
2024
Q1 		$11.2M Sell
1,285,000
-56,800
-4% -$689K 0.03% 502
2023
Q4 		$15.4M Sell
1,341,800
-503,800
-27% -$4.98M 0.04% 396
2023
Q3 		$17.8M Sell
1,845,600
-720,300
-28% -$7.06M 0.05% 337
2023
Q2 		$27.3M Buy
2,565,900
+611,000
+31% +$6.57M 0.07% 256
2023
Q1 		$20.6M Buy
1,954,900
+236,000
+14% +$2.64M 0.05% 327
2022
Q4 		$21.3M Buy
1,718,900
+1,200,200
+231% +$13.6M 0.06% 318
2022
Q3 		$5.37M Sell
518,700
-122,900
-19% -$1.39M 0.02% 699
2022
Q2 		$7.4M Sell
641,600
-76,700
-11% -$904K 0.02% 609
2022
Q1 		$9.04M Buy
718,300
+622,500
+650% +$7.14M 0.02% 556
2021
Q4 		$1.12M Sell
95,800
-507,057
-84% -$6.22M ﹤0.01% 1512
2021
Q3 		$7.87M Buy
602,857
+483,000
+403% +$6.24M 0.02% 589
2021
Q2 		$1.54M Sell
119,857
-334,000
-74% -$3.82M ﹤0.01% 1433
2021
Q1 		$5.07M Sell
453,857
-179,000
-28% -$1.89M 0.01% 844
2020
Q4 		$7.21M Sell
632,857
-103,000
-14% -$1.13M 0.02% 689
2020
Q3 		$6.62M Sell
735,857
-263,200
-26% -$2.62M 0.02% 669
2020
Q2 		$10.3M Sell
999,057
-160,400
-14% -$1.64M 0.03% 537
2020
Q1 		$11.7M Sell
1,159,457
-179,000
-13% -$2.1M 0.04% 434
2019
Q4 		$17.8M Buy
1,338,457
+1,018,100
+318% +$11.2M 0.04% 419
2019
Q3 		$2.75M Sell
320,357
-500
-0.2% -$4.86K 0.01% 990
2019
Q2 		$3.51M Sell
320,857
-62,246
-16% -$697K 0.01% 969
2019
Q1 		$4.34M Buy
383,103
+331,574
+643% +$3.7M 0.01% 886
2018
Q4 		$447K Buy
51,529
+9,552
+23% +$110K ﹤0.01% 1815
2018
Q3 		$649K Buy
+41,977
New +$664K ﹤0.01% 1699
2017
Q2 		– Sell
-64,425
Closed -$921K – 2317
2017
Q1 		$921K Sell
64,425
-8,238
-11% -$113K ﹤0.01% 1622
2016
Q4 		$931K Sell
72,663
-10,746
-13% -$136K ﹤0.01% 1594
2016
Q3 		$1.11M Buy
83,409
+46,327
+125% +$542K ﹤0.01% 1302
2016
Q2 		$406K Buy
37,082
+11,224
+43% +$110K ﹤0.01% 1599
2016
Q1 		$237K Sell
25,858
-8,358
-24% -$68.9K ﹤0.01% 1764
2015
Q4 		$332K Buy
+34,216
New +$331K ﹤0.01% 1484
2015
Q2 		– Sell
-19,769
Closed -$265K – 1972
2015
Q1 		$265K Buy
+19,769
New +$259K ﹤0.01% 1630
2014
Q3 		– Sell
-14,754
Closed -$189K – 2495
2014
Q2 		$189K Buy
+14,754
New +$160K ﹤0.01% 2292

Other funds holding IRWD

AC
Armistice Capital New York $5.62B AUM 36.06% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
SCM
Sarissa Capital Management Greenwich, Connecticut $158M AUM 103.7% 1-Year Est. Return
Bank of America
Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
AQR Capital Management
AQR Capital Management Greenwich, Connecticut $218B AUM 29.41% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
Acadian Asset Management
Acadian Asset Management Boston, Massachusetts $70.5B AUM 36% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Two Sigma Advisers's IRWD Position: Q1 2026 in Review

Two Sigma Advisers sold out of Ironwood Pharmaceuticals (IRWD) in Q1 2026, closing a stake of 3,140,100 shares — an estimated $10.6M sold.

Two Sigma Advisers first reported a position in IRWD in Q2 2014 and held it in 38 quarters. The position peaked at $27.3M in Q2 2023. 226 funds tracked by Wall St. Rank hold IRWD as of Q1 2026.

  • Two Sigma Advisers reported no remaining Ironwood Pharmaceuticals position as of Q1 2026 after selling out during the quarter.
  • Two Sigma Advisers sold 3,140,100 Ironwood Pharmaceuticals shares in Q1 2026, an estimated $10.6M.
  • Two Sigma Advisers first reported a position in Ironwood Pharmaceuticals in Q2 2014 and held it in 38 quarters.
  • Two Sigma Advisers's Ironwood Pharmaceuticals position peaked at $27.3M in Q2 2023.
  • 226 funds tracked by Wall St. Rank held Ironwood Pharmaceuticals as of Q1 2026.

Based on Two Sigma Advisers's 13F filing for Q1 2026.