Two Sigma Advisers
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Two Sigma Advisers’s Annexon ANNX Stock Holding History

Two Sigma Advisers’s Portfolio ANNX Stock Details ANNX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-23,800
Closed -$72.6K – 2345
2025
Q3 		$72.6K Buy
+23,800
New +$59.1K ﹤0.01% 2251
2025
Q1 		– Sell
-17,400
Closed -$89.3K – 2378
2024
Q4 		$89.3K Sell
17,400
-19,800
-53% -$122K ﹤0.01% 2231
2024
Q3 		$220K Sell
37,200
-82,200
-69% -$487K ﹤0.01% 2033
2024
Q2 		$585K Sell
119,400
-75,000
-39% -$388K ﹤0.01% 1810
2024
Q1 		$1.39M Buy
194,400
+109,600
+129% +$569K ﹤0.01% 1409
2023
Q4 		$385K Sell
84,800
-70,400
-45% -$174K ﹤0.01% 2024
2023
Q3 		$366K Sell
155,200
-94,900
-38% -$287K ﹤0.01% 1910
2023
Q2 		$880K Buy
250,100
+147,100
+143% +$643K ﹤0.01% 1587
2023
Q1 		$397K Buy
103,000
+9,800
+11% +$53.9K ﹤0.01% 2034
2022
Q4 		$482K Sell
93,200
-24,600
-21% -$135K ﹤0.01% 1892
2022
Q3 		$728K Sell
117,800
-38,300
-25% -$207K ﹤0.01% 1683
2022
Q2 		$588K Buy
156,100
+31,000
+25% +$94.7K ﹤0.01% 1845
2022
Q1 		$342K Buy
+125,100
New +$770K ﹤0.01% 2164

Other funds holding ANNX

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
RG
Redmile Group San Francisco, California $1.51B AUM 164.17% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return
BCLSI
Bain Capital Life Sciences Investors Boston, Massachusetts $1.11B AUM 171.34% 1-Year Est. Return
BG
Bellevue Group Kuesnacht, Switzerland $4.2B AUM 54.85% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
Ameriprise
Ameriprise Minneapolis, Minnesota $432B AUM 30.22% 1-Year Est. Return

Two Sigma Advisers's ANNX Position: Q4 2025 in Review

Two Sigma Advisers sold out of Annexon (ANNX) in Q4 2025, closing a stake of 23,800 shares — an estimated $72.6K sold.

Two Sigma Advisers first reported a position in ANNX in Q1 2022 and held it in 13 quarters. The position peaked at $1.39M in Q1 2024. 168 funds tracked by Wall St. Rank hold ANNX as of Q4 2025.

  • Two Sigma Advisers reported no remaining Annexon position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Advisers sold 23,800 Annexon shares in Q4 2025, an estimated $72.6K.
  • Two Sigma Advisers first reported a position in Annexon in Q1 2022 and held it in 13 quarters.
  • Two Sigma Advisers's Annexon position peaked at $1.39M in Q1 2024.
  • 168 funds tracked by Wall St. Rank held Annexon as of Q4 2025.

Based on Two Sigma Advisers's 13F filing for Q4 2025, filed 17 Feb 2026.