Two Sigma Advisers
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Two Sigma Advisers’s AC Immune ACIU Stock Holding History

Two Sigma Advisers’s Portfolio ACIU Stock Details ACIU Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-20,938
Closed -$60.5K – 2331
2025
Q3 		$60.5K Sell
20,938
-7,872
-27% -$17.8K ﹤0.01% 2262
2025
Q2 		$58.5K Buy
28,810
+5,200
+22% +$9.05K ﹤0.01% 2247
2025
Q1 		$44.2K Buy
23,610
+10,200
+76% +$25.7K ﹤0.01% 2327
2024
Q4 		$36.2K Buy
+13,410
New +$41.9K ﹤0.01% 2305
2022
Q2 		– Sell
-23,644
Closed -$95K – 2625
2022
Q1 		$95K Sell
23,644
-70,200
-75% -$304K ﹤0.01% 2513
2021
Q4 		$465K Sell
93,844
-18,900
-17% -$110K ﹤0.01% 1946
2021
Q3 		$757K Buy
112,744
+21,600
+24% +$155K ﹤0.01% 1740
2021
Q2 		$723K Buy
91,144
+76,200
+510% +$527K ﹤0.01% 1774
2021
Q1 		$114K Buy
+14,944
New +$107K ﹤0.01% 2432
2020
Q3 		– Sell
-14,944
Closed -$101K – 2376
2020
Q2 		$101K Buy
14,944
+3,244
+28% +$23.6K ﹤0.01% 2356
2020
Q1 		$81K Buy
+11,700
New +$91.5K ﹤0.01% 2325

Other funds holding ACIU

BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
Wells Fargo
Wells Fargo San Francisco, California $530B AUM 22.01% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Acadian Asset Management
Acadian Asset Management Boston, Massachusetts $70.5B AUM 36% 1-Year Est. Return
Point72 Asset Management
Point72 Asset Management Stamford, Connecticut $78.1B AUM 55.25% 1-Year Est. Return
Arrowstreet Capital
Arrowstreet Capital Boston, Massachusetts $185B AUM 39.58% 1-Year Est. Return
Northern Trust
Northern Trust Chicago, Illinois $757B AUM 28.64% 1-Year Est. Return
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return

Two Sigma Advisers's ACIU Position: Q4 2025 in Review

Two Sigma Advisers sold out of AC Immune (ACIU) in Q4 2025, closing a stake of 20,938 shares — an estimated $60.5K sold.

Two Sigma Advisers first reported a position in ACIU in Q1 2020 and held it in 11 quarters. The position peaked at $757K in Q3 2021. 41 funds tracked by Wall St. Rank hold ACIU as of Q4 2025.

  • Two Sigma Advisers reported no remaining AC Immune position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Advisers sold 20,938 AC Immune shares in Q4 2025, an estimated $60.5K.
  • Two Sigma Advisers first reported a position in AC Immune in Q1 2020 and held it in 11 quarters.
  • Two Sigma Advisers's AC Immune position peaked at $757K in Q3 2021.
  • 41 funds tracked by Wall St. Rank held AC Immune as of Q4 2025.

Based on Two Sigma Advisers's 13F filing for Q4 2025, filed 17 Feb 2026.