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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+18.65%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$1.93B
AUM Growth
+$160M
Cap. Flow
+$578K
Cap. Flow %
0.03%
Top 10 Hldgs %
48.49%
Holding
131
New
15
Increased
21
Reduced
19
Closed
21

Top Buys

Rank Stock Value
1
DYN icon
Dyne Therapeutics
DYN
+$23.3M
2
BCAX
Bicara Therapeutics
BCAX
+$23.2M
3
EWTX icon
Edgewise Therapeutics
EWTX
+$21.1M
4
MLTX icon
MoonLake Immunotherapeutics
MLTX
+$20.7M
5
AVBP icon
ArriVent BioPharma
AVBP
+$14.5M

Top Sells

Rank Stock Value
1
BPMC
Blueprint Medicines
BPMC
+$64.3M
2
SLNO
Soleno Therapeutics
SLNO
+$19.5M
3
PRTA icon
Prothena Corp
PRTA
+$15.9M
4
SMMT icon
Summit Therapeutics
SMMT
+$13.4M
5
NAMS icon
NewAmsterdam Pharma
NAMS
+$13.1M

Sector Composition

Rank Sector Weight
1 Healthcare 90.42%
2 Technology 4.93%
3 Communication Services 2.51%
4 Consumer Discretionary 1.07%
5 Real Estate 0.77%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PYPL icon
126
PayPal
PYPL
$50.5B
– –
-20,000
Closed -$1.3M
RACE icon
127
Ferrari
RACE
$72.5B
– –
-1,500
Closed -$636K
SMMT icon
128
Summit Therapeutics
SMMT
$11.1B
– –
-695,000
Closed -$13.4M
USB icon
129
US Bancorp
USB
$99.6B
– –
-12,500
Closed -$528K
SARO
130
StandardAero Inc
SARO
$9.7B
– –
-56,855
Closed -$1.51M
MTSR
131
DELISTED
Metsera Inc
MTSR
– –
-150,000
Closed -$4.08M
2 3 4 5
6

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Siren LLC's Q2 2025 Portfolio in Review

As of Q2 2025, Siren LLC held 131 positions worth $1.93B, up 9% from $1.77B the previous quarter. Its ten largest holdings account for 48% of the portfolio.

Siren LLC's Q2 2025 filing shows 15 new, 21 increased, 19 reduced and 21 closed positions. Its largest new stake was MoonLake Immunotherapeutics: 508,267 shares worth $24M. The largest sale was Blueprint Medicines, an estimated $64.3M.

By sector, the portfolio is most concentrated in Healthcare at 90% of assets, up from 90% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q2 2025 buy was MoonLake Immunotherapeutics: 508,267 shares worth $24M.
  • Siren LLC added most to Dyne Therapeutics in Q2 2025, an estimated $23.3M increase.
  • Siren LLC's biggest Q2 2025 reduction was Soleno Therapeutics, cutting an estimated $19.5M.
  • Siren LLC fully exited Blueprint Medicines in Q2 2025, selling an estimated $64.3M.
  • Siren LLC's ten largest holdings make up 48% of its $1.93B portfolio in Q2 2025.
  • Siren LLC opened 15 new positions and closed 21 in Q2 2025.
  • Siren LLC's portfolio value rose 9% quarter-over-quarter to $1.93B.

Based on Siren LLC's 13F filing for Q2 2025, filed 13 Aug 2025.