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Siren LLC Portfolio holdings
AUM
$3.61B
1-Year Est. Return
203.3%
This Fund
S&P 500
This Quarter
Est. Return
+74.07%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$2.26B
AUM Growth
+$263M
(+13%)
Cap. Flow
+$190M
Cap. Flow
% of AUM
8.39%
Top 10 Holdings %
Top 10 Hldgs %
48.54%
Holding
134
New
22
Increased
21
Reduced
22
Closed
16
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
SEPN
Septerna Inc
SEPN
|
+$52.1M |
| 2 |
BCYC
Bicycle Therapeutics
BCYC
|
+$39.4M |
| 3 |
Apogee Therapeutics
APGE
|
+$38.1M |
| 4 |
Madrigal Pharmaceuticals
MDGL
|
+$35.4M |
| 5 |
NewAmsterdam Pharma
NAMS
|
+$25M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Scholar Rock
SRRK
|
+$65.4M |
| 2 |
LBPH
Longboard Pharmaceuticals, Inc. Common Stock
LBPH
|
+$30.1M |
| 3 |
Wave Life Sciences
WVE
|
+$26.3M |
| 4 |
argenx
ARGX
|
+$16.8M |
| 5 |
Biohaven
BHVN
|
+$14.2M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Healthcare | 92.88% |
| 2 | Technology | 3.51% |
| 3 | Communication Services | 1.85% |
| 4 | Consumer Discretionary | 0.74% |
| 5 | Real Estate | 0.35% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
|
OMGA
101
DELISTED
Omega Therapeutics, Inc. Common Stock
OMGA
| $987K | 0.04% |
1,323,530
| – | – |
|
|
BASE
102
DELISTED
Couchbase
BASE
| $935K | 0.04% |
+60,000
| New | +$1.02M |
|
|
ACHL
103
DELISTED
Achilles Therapeutics
ACHL
| $861K | 0.04% |
755,375
| – | – |
|
104
Ferrari
RACE
$72.5B
| $854K | 0.04% |
+2,000
| New | +$902K |
|
105
Intel
INTC
$513B
| $802K | 0.04% |
40,000
| – | – |
|
|
KRON
106
DELISTED
Kronos Bio
KRON
| $801K | 0.04% |
842,954
| – | – |
|
107
Dollar Tree
DLTR
$25.2B
| $749K | 0.03% |
10,000
| – | – |
|
108
Occidental Petroleum
OXY
$55.9B
| $741K | 0.03% |
15,000
-20,000
| -57% | -$1.01M |
|
109
Meta Platforms (Facebook)
META
$1.51T
| $586K | 0.03% |
1,000
-500
| -33% | -$293K |
|
110
Marvell Technology
MRVL
$196B
| $552K | 0.02% |
+5,000
| New | +$464K |
|
111
Nu Holdings
NU
$66.9B
| $518K | 0.02% |
50,000
| – | – |
|
112
Ironwood Pharmaceuticals
IRWD
$714M
| $490K | 0.02% |
110,532
| – | – |
|
113
monday.com
MNDY
$3.94B
| $471K | 0.02% |
+2,000
| New | +$554K |
|
|
SEMR
114
DELISTED
Semrush
SEMR
| $416K | 0.02% |
+35,000
| New | +$470K |
|
115
Cyclerion Therapeutics
CYCN
$16.7M
| $374K | 0.02% |
116,155
| – | – |
|
116
Kanzhun
BZ
$7.36B
| $345K | 0.02% |
25,000
| – | – |
|
117
CALL
Gossamer Bio
GOSS
$87M
| $187K | 0.01% |
207,000
| – | – |
|
118
Caribou Biosciences
CRBU
$164M
| $168K | 0.01% |
105,347
| – | – |
|
119
ADC Therapeutics
ADCT
$144M
| – | – |
-1,163,461
| Closed | -$3.66M |
|
|
AGEN
120
Agenus
AGEN
$290M
| – | – |
-775,000
| Closed | -$4.25M |
|
|
121
Biohaven
BHVN
$2.21B
| – | – |
-283,540
| Closed | -$14.2M |
|
|
CBIO
122
Crescent Biopharma
CBIO
$626M
| – | – |
-19,651
| Closed | -$332K |
|
123
Neurogene
NGNE
$712M
| – | – |
-175,898
| Closed | -$7.38M |
|
124
Natera
NTRA
$46.4B
| – | – |
-12,594
| Closed | -$1.6M |
|
125
NovoCure
NVCR
$1.91B
| – | – |
-350,884
| Closed | -$5.48M |
|
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Siren LLC's Q4 2024 Portfolio in Review
As of Q4 2024, Siren LLC held 134 positions worth $2.26B, up 13% from $2B the previous quarter. Its ten largest holdings account for 49% of the portfolio.
Siren LLC deployed $190M of net new capital in Q4 2024, opening 22 new positions and adding to 21 existing holdings. Its largest new stake was Septerna Inc: 2,202,514 shares worth $50.4M.
By sector, the portfolio is most concentrated in Healthcare at 93% of assets, down from 93% a quarter earlier, followed by Technology and Communication Services.
On the sell side, the largest reduction was Scholar Rock, an estimated $65.4M trimmed.
- Siren LLC's largest Q4 2024 buy was Septerna Inc: 2,202,514 shares worth $50.4M.
- Siren LLC added most to NewAmsterdam Pharma in Q4 2024, an estimated $25M increase.
- Siren LLC's biggest Q4 2024 reduction was Scholar Rock, cutting an estimated $65.4M.
- Siren LLC fully exited Longboard Pharmaceuticals, Inc. Common Stock in Q4 2024, selling an estimated $30.1M.
- Siren LLC's ten largest holdings make up 49% of its $2.26B portfolio in Q4 2024.
- Siren LLC opened 22 new positions and closed 16 in Q4 2024.
- Siren LLC's portfolio value rose 13% quarter-over-quarter to $2.26B.
Based on Siren LLC's 13F filing for Q4 2024, filed 14 Feb 2025.