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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+74.07%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$2.26B
AUM Growth
+$263M
Cap. Flow
+$190M
Cap. Flow %
8.39%
Top 10 Hldgs %
48.54%
Holding
134
New
22
Increased
21
Reduced
22
Closed
16

Top Buys

Rank Stock Value
1
SEPN
Septerna Inc
SEPN
+$52.1M
2
BCYC
Bicycle Therapeutics
BCYC
+$39.4M
3
APGE icon
Apogee Therapeutics
APGE
+$38.1M
4
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$35.4M
5
NAMS icon
NewAmsterdam Pharma
NAMS
+$25M

Top Sells

Rank Stock Value
1
SRRK icon
Scholar Rock
SRRK
+$65.4M
2
LBPH
Longboard Pharmaceuticals, Inc. Common Stock
LBPH
+$30.1M
3
WVE icon
Wave Life Sciences
WVE
+$26.3M
4
ARGX icon
argenx
ARGX
+$16.8M
5
BHVN icon
Biohaven
BHVN
+$14.2M

Sector Composition

Rank Sector Weight
1 Healthcare 92.88%
2 Technology 3.51%
3 Communication Services 1.85%
4 Consumer Discretionary 0.74%
5 Real Estate 0.35%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
FHTX icon
76
Foghorn Therapeutics
FHTX
$360M
$3.4M 0.15%
720,720
– –
VIGL
77
DELISTED
Vigil Neuroscience
VIGL
$3.38M 0.15%
1,991,038
– –
NBIS
78
Nebius Group N.V.
NBIS
$47.7B
$3.32M 0.15%
+120,000
New +$2.93M
SGMT icon
79
Sagimet Biosciences
SGMT
$559M
$3.26M 0.14%
724,771
– –
GBIO
80
DELISTED
Generation Bio
GBIO
$3.16M 0.14%
298,273
– –
TSM icon
81
TSMC
TSM
$2.18T
$2.96M 0.13%
15,000
-10,000
-40% -$1.94M
FCX icon
82
Freeport-McMoran
FCX
$97.5B
$2.86M 0.13%
+75,000
New +$3.36M
KLRS
83
Kalaris Therapeutics
KLRS
$96.8M
$2.77M 0.12%
286,833
– –
OVID icon
84
Ovid Therapeutics
OVID
$491M
$2.66M 0.12%
2,850,000
– –
SE icon
85
Sea Limited
SE
$69.5B
$2.65M 0.12%
25,000
-12,500
-33% -$1.31M
ESTC icon
86
Elastic
ESTC
$7.81B
$2.48M 0.11%
25,000
+12,000
+92% +$1.11M
QCOM icon
87
Qualcomm
QCOM
$176B
$2.3M 0.1%
15,000
– –
BIOA
88
BioAge Labs
BIOA
$538M
$2.25M 0.1%
388,000
+88,000
+29% +$1.52M
BDTX icon
89
Black Diamond Therapeutics
BDTX
$112M
$2.24M 0.1%
1,046,517
– –
RGNX icon
90
Regenxbio
RGNX
$708M
$2.2M 0.1%
284,000
– –
TRML
91
DELISTED
Tourmaline Bio
TRML
$1.85M 0.08%
91,426
– –
PCOR icon
92
Procore
PCOR
$8.67B
$1.5M 0.07%
20,000
-12,300
-38% -$873K
APLT
93
DELISTED
Applied Therapeutics
APLT
$1.4M 0.06%
1,633,768
– –
GOOGL icon
94
Alphabet (Google) Class A
GOOGL
$4.33T
$1.33M 0.06%
7,000
-4,000
-36% -$700K
PYPL icon
95
PayPal
PYPL
$50.5B
$1.28M 0.06%
15,000
– –
HOOK
96
DELISTED
HOOKIPA Pharma
HOOK
$1.14M 0.05%
566,640
– –
HCA icon
97
HCA Healthcare
HCA
$89.5B
$1.13M 0.05%
+3,750
New +$1.31M
BEKE icon
98
KE Holdings
BEKE
$18.8B
$1.11M 0.05%
60,000
-40,000
-40% -$825K
WK icon
99
Workiva
WK
$3.54B
$1.09M 0.05%
+10,000
New +$922K
PANW icon
100
Palo Alto Networks
PANW
$297B
$1.09M 0.05%
6,000
-3,000
-33% -$567K
2 3
4
5 6

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ACM
Advent Capital Management New York $3.63B AUM 0.29% 1-Year Est. Return
GCM
Ghisallo Capital Management Boston, Massachusetts $3.63B AUM 30.51% 1-Year Est. Return
VI
Vestcor Inc Fredericton, New Brunswick, Canada $3.63B AUM 21.49% 1-Year Est. Return
BPS
BNDES Participacoes SA Rio De Janeiro, Brazil $3.58B AUM
VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return
WWA
WCG Wealth Advisors Las Vegas, Nevada $3.57B AUM 18.63% 1-Year Est. Return
OCM
One Capital Management Westlake Village, California $3.65B AUM 15.32% 1-Year Est. Return

Siren LLC's Q4 2024 Portfolio in Review

As of Q4 2024, Siren LLC held 134 positions worth $2.26B, up 13% from $2B the previous quarter. Its ten largest holdings account for 49% of the portfolio.

Siren LLC deployed $190M of net new capital in Q4 2024, opening 22 new positions and adding to 21 existing holdings. Its largest new stake was Septerna Inc: 2,202,514 shares worth $50.4M.

By sector, the portfolio is most concentrated in Healthcare at 93% of assets, down from 93% a quarter earlier, followed by Technology and Communication Services.

On the sell side, the largest reduction was Scholar Rock, an estimated $65.4M trimmed.

  • Siren LLC's largest Q4 2024 buy was Septerna Inc: 2,202,514 shares worth $50.4M.
  • Siren LLC added most to NewAmsterdam Pharma in Q4 2024, an estimated $25M increase.
  • Siren LLC's biggest Q4 2024 reduction was Scholar Rock, cutting an estimated $65.4M.
  • Siren LLC fully exited Longboard Pharmaceuticals, Inc. Common Stock in Q4 2024, selling an estimated $30.1M.
  • Siren LLC's ten largest holdings make up 49% of its $2.26B portfolio in Q4 2024.
  • Siren LLC opened 22 new positions and closed 16 in Q4 2024.
  • Siren LLC's portfolio value rose 13% quarter-over-quarter to $2.26B.

Based on Siren LLC's 13F filing for Q4 2024, filed 14 Feb 2025.