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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+74.07%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$2.26B
AUM Growth
+$263M
Cap. Flow
+$190M
Cap. Flow %
8.39%
Top 10 Hldgs %
48.54%
Holding
134
New
22
Increased
21
Reduced
22
Closed
16

Top Buys

Rank Stock Value
1
SEPN
Septerna Inc
SEPN
+$52.1M
2
BCYC
Bicycle Therapeutics
BCYC
+$39.4M
3
APGE icon
Apogee Therapeutics
APGE
+$38.1M
4
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$35.4M
5
NAMS icon
NewAmsterdam Pharma
NAMS
+$25M

Top Sells

Rank Stock Value
1
SRRK icon
Scholar Rock
SRRK
+$65.4M
2
LBPH
Longboard Pharmaceuticals, Inc. Common Stock
LBPH
+$30.1M
3
WVE icon
Wave Life Sciences
WVE
+$26.3M
4
ARGX icon
argenx
ARGX
+$16.8M
5
BHVN icon
Biohaven
BHVN
+$14.2M

Sector Composition

Rank Sector Weight
1 Healthcare 92.88%
2 Technology 3.51%
3 Communication Services 1.85%
4 Consumer Discretionary 0.74%
5 Real Estate 0.35%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SYRE icon
51
Spyre Therapeutics
SYRE
$9.25B
$8.71M 0.38%
+374,000
New +$11M
CRWD icon
52
CrowdStrike
CRWD
$218B
$8.21M 0.36%
96,000
-4,000
-4% -$333K
IOVA icon
53
Iovance Biotherapeutics
IOVA
$2.87B
$8.18M 0.36%
1,106,040
– –
ORIC icon
54
Oric Pharmaceuticals
ORIC
$1.4B
$8.13M 0.36%
1,007,575
– –
TNGX icon
55
Tango Therapeutics
TNGX
$4.41B
$8.05M 0.36%
2,603,897
– –
AMZN icon
56
Amazon
AMZN
$2.96T
$8.01M 0.35%
36,500
+1,750
+5% +$358K
RCKT icon
57
Rocket Pharmaceuticals
RCKT
$394M
$7.54M 0.33%
+600,000
New +$9.03M
IONQ icon
58
IonQ
IONQ
$16.6B
$7.1M 0.31%
170,000
-330,000
-66% -$8.28M
IHS icon
59
IHS Holding
IHS
$2.81B
$6.88M 0.3%
2,357,520
– –
RAPP
60
Rapport Therapeutics
RAPP
$2.18B
$6.82M 0.3%
384,197
– –
NVDA icon
61
NVIDIA
NVDA
$5.42T
$6.57M 0.29%
48,932
– –
NOW icon
62
ServiceNow
NOW
$129B
$5.94M 0.26%
28,025
-9,475
-25% -$1.92M
SLRN
63
DELISTED
ACELYRIN
SLRN
$5.43M 0.24%
1,729,665
– –
PDD icon
64
Pinduoduo
PDD
$131B
$5.13M 0.23%
52,901
+12,500
+31% +$1.45M
GOSS icon
65
Gossamer Bio
GOSS
$87M
$4.71M 0.21%
5,208,968
-8,072,642
-61% -$6.92M
DT icon
66
Dynatrace
DT
$14.2B
$4.5M 0.2%
82,729
– –
BA icon
67
Boeing
BA
$185B
$4.42M 0.2%
+25,000
New +$3.92M
EDU icon
68
New Oriental
EDU
$8.98B
$4.4M 0.19%
68,500
+30,000
+78% +$1.92M
DDOG icon
69
Datadog
DDOG
$84B
$4.35M 0.19%
30,425
-2,500
-8% -$343K
PRQR icon
70
ProQR Therapeutics
PRQR
$265M
$4.17M 0.18%
+1,575,000
New +$5M
LXEO icon
71
Lexeo Therapeutics
LXEO
$378M
$3.97M 0.18%
603,435
– –
ADBE icon
72
Adobe
ADBE
$105B
$3.91M 0.17%
8,798
+7,798
+780% +$3.86M
PHAT icon
73
Phathom Pharmaceuticals
PHAT
$692M
$3.74M 0.17%
460,753
– –
TIL icon
74
Instil Bio
TIL
$50.3M
$3.67M 0.16%
192,433
– –
FROG icon
75
JFrog
FROG
$10.8B
$3.53M 0.16%
120,116
+59,116
+97% +$1.79M
1 2
3
4 5

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GCM
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OCM
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Siren LLC's Q4 2024 Portfolio in Review

As of Q4 2024, Siren LLC held 134 positions worth $2.26B, up 13% from $2B the previous quarter. Its ten largest holdings account for 49% of the portfolio.

Siren LLC deployed $190M of net new capital in Q4 2024, opening 22 new positions and adding to 21 existing holdings. Its largest new stake was Septerna Inc: 2,202,514 shares worth $50.4M.

By sector, the portfolio is most concentrated in Healthcare at 93% of assets, down from 93% a quarter earlier, followed by Technology and Communication Services.

On the sell side, the largest reduction was Scholar Rock, an estimated $65.4M trimmed.

  • Siren LLC's largest Q4 2024 buy was Septerna Inc: 2,202,514 shares worth $50.4M.
  • Siren LLC added most to NewAmsterdam Pharma in Q4 2024, an estimated $25M increase.
  • Siren LLC's biggest Q4 2024 reduction was Scholar Rock, cutting an estimated $65.4M.
  • Siren LLC fully exited Longboard Pharmaceuticals, Inc. Common Stock in Q4 2024, selling an estimated $30.1M.
  • Siren LLC's ten largest holdings make up 49% of its $2.26B portfolio in Q4 2024.
  • Siren LLC opened 22 new positions and closed 16 in Q4 2024.
  • Siren LLC's portfolio value rose 13% quarter-over-quarter to $2.26B.

Based on Siren LLC's 13F filing for Q4 2024, filed 14 Feb 2025.