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Simplify Asset Management

Simplify Asset Management Portfolio holdings

AUM $7.19B Turnover 25.77%
1-Year Est. Return 6.88%
This Fund
S&P 500
This Quarter Est. Return
+0.82%
1 Year Est. Return
+6.88%
3 Year Est. Return
+44.98%
5 Year Est. Return
+50.08%
10 Year Est. Return
–
AUM
$6.13B
AUM Growth
+$696M
Cap. Flow
+$1.14B
Cap. Flow %
18.61%
Top 10 Hldgs %
92.45%
Holding
166
New
37
Increased
75
Reduced
18
Closed
24
Avg Time Held Equity + Options
0.9 years
Top 10 Avg Time Held Equity + Options
1.3 years
Top 20 Avg Time Held Equity + Options
0.9 years
Avg Time Held Equity only
0.9 years
Top 10 Avg Time Held Equity only
1.3 years
Top 20 Avg Time Held Equity only
1 year

Sector Composition

Rank Sector Weight
1 Miscellaneous 92.9%
2 Healthcare 5.76%
3 Energy 0.41%
4 Industrials 0.31%
5 Technology 0.2%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake
Capital Flow Held Since
VRTX icon
26
Vertex Pharmaceuticals
VRTX
$129B
$7.93M 0.13%
17,492
+16,267
+1,328% +$7.01M
2024 Q4
4 quarters
TXG icon
27
10x Genomics
TXG
$9.43B
$7.93M 0.13%
+485,977
New +$7.34M
2025 Q4
0 quarters
EYPT icon
28
EyePoint Inc
EYPT
$271M
$6.86M 0.11%
375,264
+284,824
+315% +$4.04M
2025 Q1
3 quarters
AZN icon
29
AstraZeneca
AZN
$259B
$6.53M 0.11%
35,490
+17,018
+92% +$2.98M
2025 Q1
3 quarters
INSM icon
30
Insmed
INSM
$21.7B
$6.42M 0.1%
36,890
+17,226
+88% +$3.14M
2024 Q4
4 quarters
ACHV icon
31
Achieve Life Sciences
ACHV
$719M
$5.89M 0.1%
1,184,512
– –
2024 Q1
7 quarters
CVS icon
32
CVS Health
CVS
$118B
$5.88M 0.1%
74,124
-10,802
-13% -$852K
2024 Q4
4 quarters
TSLA icon
33
Tesla
TSLA
$1.43T
$5.78M 0.09%
12,843
-11,517
-47% -$5.11M
2020 Q4
20 quarters
ABBV icon
34
AbbVie
ABBV
$501B
$5.43M 0.09%
23,777
-13,106
-36% -$2.99M
2025 Q1
3 quarters
PHAT icon
35
Phathom Pharmaceuticals
PHAT
$607M
$5.34M 0.09%
321,935
– –
2023 Q1
11 quarters
ESTA icon
36
Establishment Labs
ESTA
$1.83B
$5.31M 0.09%
72,894
+34,946
+92% +$2.11M
2025 Q3
1 quarter
ALHC icon
37
Alignment Healthcare
ALHC
$1.69B
$5.19M 0.08%
262,880
+125,946
+92% +$2.26M
2024 Q4
4 quarters
PEN icon
38
Penumbra
PEN
$12.7B
$4.92M 0.08%
15,827
+7,485
+90% +$2.07M
2025 Q3
1 quarter
QQQ icon
39
PUT
Invesco QQQ Trust
QQQ
$487B
$4.9M 0.08%
+8,000
New +$4.91M
2025 Q4
0 quarters
HODL icon
40
VanEck Bitcoin Trust
HODL
$1.37B
$4.77M 0.08%
192,930
-42,062
-18% -$1.19M
2025 Q1
3 quarters
GILD icon
41
Gilead Sciences
GILD
$195B
$4.6M 0.08%
37,479
-22,707
-38% -$2.76M
2024 Q3
5 quarters
JNJ icon
42
Johnson & Johnson
JNJ
$610B
$4.54M 0.07%
21,960
+10,558
+93% +$2.09M
2021 Q4
16 quarters
GEHC icon
43
GE HealthCare
GEHC
$31.8B
$4.43M 0.07%
54,028
+25,844
+92% +$2.01M
2025 Q2
2 quarters
MLYS icon
44
Mineralys Therapeutics
MLYS
$1.91B
$4.14M 0.07%
114,182
-104,544
-48% -$4.19M
2025 Q3
1 quarter
IQV icon
45
IQVIA
IQV
$44.6B
$3.93M 0.06%
17,418
+8,374
+93% +$1.82M
2025 Q2
2 quarters
VRDN icon
46
Viridian Therapeutics
VRDN
$2.22B
$3.22M 0.05%
103,531
+53,531
+107% +$1.47M
2025 Q3
1 quarter
XXV icon
47
Simplify Ancorato Target 25 Distribution ETF
XXV
$49.5M
$3.18M 0.05%
+125,000
New +$3.2M
2025 Q4
0 quarters
MIST icon
48
Milestone Pharmaceuticals
MIST
$98.9M
$3.04M 0.05%
1,506,405
-1,326,569
-47% -$2.86M
2025 Q1
3 quarters
GH icon
49
Guardant Health
GH
$22.3B
$3.02M 0.05%
29,581
-1,519
-5% -$136K
2025 Q2
2 quarters
OSCR icon
50
Oscar Health
OSCR
$10.3B
$2.95M 0.05%
+205,131
New +$3.55M
2025 Q4
0 quarters

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Simplify Asset Management's Q4 2025 Portfolio in Review

As of Q4 2025, Simplify Asset Management held 166 positions worth $6.13B, up 13% from $5.43B the previous quarter. Its ten largest holdings account for 92% of the portfolio.

Simplify Asset Management deployed $1.14B of net new capital in Q4 2025, opening 37 new positions and adding to 75 existing holdings. Its largest new stake was Amgen: 52,350 shares worth $17.1M.

By sector, the portfolio is most concentrated in Miscellaneous at 93% of assets, down from 95% a quarter earlier, followed by Healthcare and Energy.

On the sell side, the largest reduction was Simplify Aggregate Bond ETF, an estimated $38.7M trimmed.

  • Simplify Asset Management's largest Q4 2025 buy was Amgen: 52,350 shares worth $17.1M.
  • Simplify Asset Management added most to Simplify Government Money Market ETF in Q4 2025, an estimated $1.05B increase.
  • Simplify Asset Management's biggest Q4 2025 reduction was Simplify Aggregate Bond ETF, cutting an estimated $38.7M.
  • Simplify Asset Management fully exited Simplify Currency Strategy ETF in Q4 2025, selling an estimated $9.3M.
  • Simplify Asset Management's ten largest holdings make up 92% of its $6.13B portfolio in Q4 2025.
  • Simplify Asset Management opened 37 new positions and closed 24 in Q4 2025.
  • Simplify Asset Management's portfolio value rose 13% quarter-over-quarter to $6.13B.

Based on Simplify Asset Management's 13F filing for Q4 2025, filed 9 Feb 2026.