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SAM

Sectoral Asset Management Portfolio holdings

AUM $121M
1-Year Est. Return 73.47%
This Fund
S&P 500
This Quarter Est. Return
+41.87%
1 Year Est. Return
+73.47%
3 Year Est. Return
+165.77%
5 Year Est. Return
+169.27%
10 Year Est. Return
+1,136.49%
AUM
$162M
AUM Growth
+$10.6M
Cap. Flow
-$25.2M
Cap. Flow %
-15.53%
Top 10 Hldgs %
35.02%
Holding
98
New
4
Increased
29
Reduced
28
Closed
16

Top Buys

Rank Stock Value
1
SI
Shoulder Innovations Inc
SI
+$6.01M
2
GPCR icon
Structure Therapeutics
GPCR
+$3.4M
3
XBI icon
State Street SPDR S&P Biotech ETF
XBI
+$3.06M
4
ANAB icon
AnaptysBio
ANAB
+$2.54M
5
TECX
Tectonic Therapeutic
TECX
+$1.94M

Top Sells

Rank Stock Value
1
LENZ
LENZ Therapeutics
LENZ
+$28.6M
2
MLYS icon
Mineralys Therapeutics
MLYS
+$7.54M
3
RAPP
Rapport Therapeutics
RAPP
+$2.43M
4
REPL icon
Replimune Group
REPL
+$2.15M
5
PVLA
Palvella Therapeutics
PVLA
+$2.07M

Sector Composition

Rank Sector Weight
1 Healthcare 97.9%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CTNM
1
Contineum Therapeutics
CTNM
$506M
$9.41M 5.81%
800,787
– –
LLY icon
2
Eli Lilly
LLY
$1.02T
$7.15M 4.42%
9,376
+400
+4% +$298K
GPCR icon
3
Structure Therapeutics
GPCR
$3.34B
$6.21M 3.83%
221,872
+170,503
+332% +$3.4M
ANAB icon
4
AnaptysBio
ANAB
$1.49B
$5.96M 3.68%
194,485
+110,585
+132% +$2.54M
SI
5
Shoulder Innovations Inc
SI
$435M
$5.4M 3.33%
+430,282
New +$6.01M
RCUS icon
6
Arcus Biosciences
RCUS
$3.54B
$5.01M 3.09%
368,070
+110,800
+43% +$1.15M
IMTX icon
7
Immatics
IMTX
$1.26B
$4.78M 2.95%
560,494
+228,224
+69% +$1.41M
UNH icon
8
UnitedHealth
UNH
$383B
$4.68M 2.89%
13,545
-3,200
-19% -$968K
BCAX
9
Bicara Therapeutics
BCAX
$1.78B
$4.21M 2.6%
266,495
+65,100
+32% +$729K
ORIC icon
10
Oric Pharmaceuticals
ORIC
$1.08B
$3.94M 2.43%
328,655
+97,170
+42% +$1.02M
SLDB icon
11
Solid Biosciences
SLDB
$832M
$3.91M 2.41%
633,052
+211,472
+50% +$1.24M
KURA icon
12
Kura Oncology
KURA
$948M
$3.5M 2.16%
395,872
+72,300
+22% +$515K
VTYX
13
DELISTED
Ventyx Biosciences
VTYX
$3.44M 2.13%
1,107,267
+175,647
+19% +$465K
ABBV icon
14
AbbVie
ABBV
$448B
$3.43M 2.12%
14,800
– –
MBX
15
MBX Biosciences
MBX
$2.86B
$3.41M 2.11%
194,898
+3,073
+2% +$41.1K
XBI icon
16
State Street SPDR S&P Biotech ETF
XBI
$10.1B
$3.41M 2.1%
+34,000
New +$3.06M
ZBIO
17
Zenas BioPharma
ZBIO
$1.94B
$3.37M 2.08%
152,025
-58,600
-28% -$954K
PVLA
18
Palvella Therapeutics
PVLA
$1.78B
$3.08M 1.9%
49,115
-46,500
-49% -$2.07M
TECX
19
Tectonic Therapeutic
TECX
$605M
$3.02M 1.87%
192,770
+93,800
+95% +$1.94M
VRTX icon
20
Vertex Pharmaceuticals
VRTX
$122B
$3.02M 1.87%
7,715
+770
+11% +$322K
AMGN icon
21
Amgen
AMGN
$197B
$2.92M 1.8%
10,340
-930
-8% -$270K
TIL icon
22
Instil Bio
TIL
$49.2M
$2.88M 1.78%
161,380
+75,160
+87% +$1.91M
ARGX icon
23
argenx
ARGX
$52.9B
$2.87M 1.77%
3,890
-195
-5% -$129K
JNJ icon
24
Johnson & Johnson
JNJ
$599B
$2.84M 1.75%
15,300
-4,000
-21% -$685K
ISRG icon
25
Intuitive Surgical
ISRG
$125B
$2.57M 1.59%
5,750
+500
+10% +$240K
1
2 3 4

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CCM
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LFWA
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FWA
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CF
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Sectoral Asset Management's Q3 2025 Portfolio in Review

As of Q3 2025, Sectoral Asset Management held 98 positions worth $162M, up 7% from $151M the previous quarter. Its ten largest holdings account for 35% of the portfolio.

Sectoral Asset Management withdrew a net $25.2M in Q3 2025, closing 16 positions and reducing 28 holdings. Its most notable exit was LENZ Therapeutics, an estimated $28.6M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 98% of assets, down from 100% a quarter earlier.

Against the trend, Sectoral Asset Management opened a new position in Shoulder Innovations Inc worth $5.4M.

  • Sectoral Asset Management's largest Q3 2025 buy was Shoulder Innovations Inc: 430,282 shares worth $5.4M.
  • Sectoral Asset Management added most to Structure Therapeutics in Q3 2025, an estimated $3.4M increase.
  • Sectoral Asset Management's biggest Q3 2025 reduction was Mineralys Therapeutics, cutting an estimated $7.54M.
  • Sectoral Asset Management fully exited LENZ Therapeutics in Q3 2025, selling an estimated $28.6M.
  • Sectoral Asset Management's ten largest holdings make up 35% of its $162M portfolio in Q3 2025.
  • Sectoral Asset Management opened 4 new positions and closed 16 in Q3 2025.
  • Sectoral Asset Management's portfolio value rose 7% quarter-over-quarter to $162M.

Based on Sectoral Asset Management's 13F filing for Q3 2025, filed 14 Nov 2025.