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SAM

Sectoral Asset Management Portfolio holdings

AUM $121M
1-Year Est. Return 73.47%
This Fund
S&P 500
This Quarter Est. Return
+15.26%
1 Year Est. Return
+73.47%
3 Year Est. Return
+165.77%
5 Year Est. Return
+169.27%
10 Year Est. Return
+1,136.49%
AUM
$125M
AUM Growth
-$37.3M
Cap. Flow
-$58.8M
Cap. Flow %
-47.11%
Top 10 Hldgs %
46.07%
Holding
88
New
6
Increased
20
Reduced
44
Closed
14

Top Buys

Rank Stock Value
1
EVMN
Evommune Inc
EVMN
+$11.1M
2
LENZ
LENZ Therapeutics
LENZ
+$1.24M
3
JNJ icon
Johnson & Johnson
JNJ
+$989K
4
COGT icon
Cogent Biosciences
COGT
+$919K
5
AMGN icon
Amgen
AMGN
+$866K

Top Sells

Rank Stock Value
1
GPCR icon
Structure Therapeutics
GPCR
+$8.08M
2
VTYX
Ventyx Biosciences
VTYX
+$7.55M
3
RCUS icon
Arcus Biosciences
RCUS
+$6.35M
4
ANAB icon
AnaptysBio
ANAB
+$5.96M
5
IMTX icon
Immatics
IMTX
+$5.02M

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
BMY icon
76
Bristol-Myers Squibb
BMY
$133B
– –
-10,800
Closed -$487K
CI icon
77
Cigna
CI
$74.8B
– –
-1,800
Closed -$519K
MLTX icon
78
MoonLake Immunotherapeutics
MLTX
$1.5B
– –
-956
Closed -$6.86K
MRUS
79
DELISTED
Merus
MRUS
– –
-11,545
Closed -$1.09M
PCVX icon
80
Vaxcyte
PCVX
$7.81B
– –
-4,205
Closed -$151K
SLDB icon
81
Solid Biosciences
SLDB
$784M
– –
-633,052
Closed -$3.91M
TIL icon
82
Instil Bio
TIL
$48.9M
– –
-161,380
Closed -$2.88M
XBI icon
83
State Street SPDR S&P Biotech ETF
XBI
$9.59B
– –
-34,000
Closed -$3.41M
ZLAB icon
84
Zai Lab
ZLAB
$2.07B
– –
-12,590
Closed -$427K
BCAX
85
Bicara Therapeutics
BCAX
$1.7B
– –
-266,495
Closed -$4.21M
MBX
86
MBX Biosciences
MBX
$3.07B
– –
-194,898
Closed -$3.41M
ZBIO
87
Zenas BioPharma
ZBIO
$1.96B
– –
-152,025
Closed -$3.37M
PVLA
88
Palvella Therapeutics
PVLA
$2B
– –
-49,115
Closed -$3.08M
1 2 3
4

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Sectoral Asset Management's Q4 2025 Portfolio in Review

As of Q4 2025, Sectoral Asset Management held 88 positions worth $125M, down 23% from $162M the previous quarter. Its ten largest holdings account for 46% of the portfolio.

Sectoral Asset Management withdrew a net $58.8M in Q4 2025, closing 14 positions and reducing 44 holdings. Its most notable exit was AnaptysBio, an estimated $5.96M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 98% a quarter earlier.

Against the trend, Sectoral Asset Management opened a new position in Evommune Inc worth $10.1M.

  • Sectoral Asset Management's largest Q4 2025 buy was Evommune Inc: 589,005 shares worth $10.1M.
  • Sectoral Asset Management added most to Johnson & Johnson in Q4 2025, an estimated $989K increase.
  • Sectoral Asset Management's biggest Q4 2025 reduction was Structure Therapeutics, cutting an estimated $8.08M.
  • Sectoral Asset Management fully exited AnaptysBio in Q4 2025, selling an estimated $5.96M.
  • Sectoral Asset Management's ten largest holdings make up 46% of its $125M portfolio in Q4 2025.
  • Sectoral Asset Management opened 6 new positions and closed 14 in Q4 2025.
  • Sectoral Asset Management's portfolio value fell 23% quarter-over-quarter to $125M.

Based on Sectoral Asset Management's 13F filing for Q4 2025, filed 9 Feb 2026.