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SAM

Sectoral Asset Management Portfolio holdings

AUM $121M
1-Year Est. Return 73.47%
This Fund
S&P 500
This Quarter Est. Return
+41.87%
1 Year Est. Return
+73.47%
3 Year Est. Return
+165.77%
5 Year Est. Return
+169.27%
10 Year Est. Return
+1,136.49%
AUM
$162M
AUM Growth
+$10.6M
Cap. Flow
-$25.2M
Cap. Flow %
-15.53%
Top 10 Hldgs %
35.02%
Holding
98
New
4
Increased
29
Reduced
28
Closed
16

Top Buys

Rank Stock Value
1
SI
Shoulder Innovations Inc
SI
+$6.01M
2
GPCR icon
Structure Therapeutics
GPCR
+$3.4M
3
XBI icon
State Street SPDR S&P Biotech ETF
XBI
+$3.06M
4
ANAB icon
AnaptysBio
ANAB
+$2.54M
5
TECX
Tectonic Therapeutic
TECX
+$1.94M

Top Sells

Rank Stock Value
1
LENZ
LENZ Therapeutics
LENZ
+$28.6M
2
MLYS icon
Mineralys Therapeutics
MLYS
+$7.54M
3
RAPP
Rapport Therapeutics
RAPP
+$2.43M
4
REPL icon
Replimune Group
REPL
+$2.15M
5
PVLA
Palvella Therapeutics
PVLA
+$2.07M

Sector Composition

Rank Sector Weight
1 Healthcare 97.9%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ALHC icon
51
Alignment Healthcare
ALHC
$3.08B
$951K 0.59%
+54,500
New +$808K
FOLD
52
DELISTED
Amicus Therapeutics
FOLD
$939K 0.58%
119,105
-480
-0.4% -$3.42K
PRVA icon
53
Privia Health
PRVA
$2.98B
$909K 0.56%
+36,500
New +$786K
VERA icon
54
Vera Therapeutics
VERA
$2.3B
$877K 0.54%
30,188
-11,230
-27% -$260K
BOLD
55
Boundless Bio
BOLD
$56.2M
$835K 0.52%
678,574
– –
SPRY icon
56
ARS Pharmaceuticals
SPRY
$509M
$822K 0.51%
81,785
+16,000
+24% +$230K
RDNT icon
57
RadNet
RDNT
$5.02B
$762K 0.47%
10,000
-2,500
-20% -$162K
ROIV icon
58
Roivant Sciences
ROIV
$24.5B
$757K 0.47%
50,007
– –
AVBP icon
59
ArriVent BioPharma
AVBP
$1.39B
$724K 0.45%
39,235
+3,655
+10% +$71.8K
ASND icon
60
Ascendis Pharma A/S
ASND
$16B
$716K 0.44%
3,601
+130
+4% +$24.2K
BBIO icon
61
BridgeBio Pharma
BBIO
$15.7B
$709K 0.44%
13,650
-2,435
-15% -$119K
OMDA
62
Omada Health Inc
OMDA
$1.18B
$608K 0.38%
27,500
-7,000
-20% -$143K
IONS icon
63
Ionis Pharmaceuticals
IONS
$8.6B
$602K 0.37%
9,205
– –
CYTK icon
64
Cytokinetics
CYTK
$10.5B
$562K 0.35%
10,223
-1,500
-13% -$61.8K
HNGE
65
Hinge Health
HNGE
$5.78B
$550K 0.34%
11,206
+2,000
+22% +$105K
PTCT icon
66
PTC Therapeutics
PTCT
$5.68B
$524K 0.32%
8,535
– –
CI icon
67
Cigna
CI
$73.7B
$519K 0.32%
1,800
– –
BMY icon
68
Bristol-Myers Squibb
BMY
$133B
$487K 0.3%
10,800
– –
ZLAB icon
69
Zai Lab
ZLAB
$2.06B
$427K 0.26%
12,590
-3,250
-21% -$112K
NBIX icon
70
Neurocrine Biosciences
NBIX
$16.8B
$416K 0.26%
2,960
– –
MDGL icon
71
Madrigal Pharmaceuticals
MDGL
$10.8B
$335K 0.21%
730
– –
BIIB icon
72
Biogen
BIIB
$30B
$333K 0.21%
2,375
– –
RPRX icon
73
Royalty Pharma
RPRX
$25.9B
$327K 0.2%
9,280
– –
UTHR icon
74
United Therapeutics
UTHR
$25.8B
$321K 0.2%
765
– –
TEM
75
Tempus AI
TEM
$7.92B
$303K 0.19%
3,760
– –
1 2
3
4

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Sectoral Asset Management's Q3 2025 Portfolio in Review

As of Q3 2025, Sectoral Asset Management held 98 positions worth $162M, up 7% from $151M the previous quarter. Its ten largest holdings account for 35% of the portfolio.

Sectoral Asset Management withdrew a net $25.2M in Q3 2025, closing 16 positions and reducing 28 holdings. Its most notable exit was LENZ Therapeutics, an estimated $28.6M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 98% of assets, down from 100% a quarter earlier.

Against the trend, Sectoral Asset Management opened a new position in Shoulder Innovations Inc worth $5.4M.

  • Sectoral Asset Management's largest Q3 2025 buy was Shoulder Innovations Inc: 430,282 shares worth $5.4M.
  • Sectoral Asset Management added most to Structure Therapeutics in Q3 2025, an estimated $3.4M increase.
  • Sectoral Asset Management's biggest Q3 2025 reduction was Mineralys Therapeutics, cutting an estimated $7.54M.
  • Sectoral Asset Management fully exited LENZ Therapeutics in Q3 2025, selling an estimated $28.6M.
  • Sectoral Asset Management's ten largest holdings make up 35% of its $162M portfolio in Q3 2025.
  • Sectoral Asset Management opened 4 new positions and closed 16 in Q3 2025.
  • Sectoral Asset Management's portfolio value rose 7% quarter-over-quarter to $162M.

Based on Sectoral Asset Management's 13F filing for Q3 2025, filed 14 Nov 2025.