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SAM

Sectoral Asset Management Portfolio holdings

AUM $121M
1-Year Est. Return 73.47%
This Fund
S&P 500
This Quarter Est. Return
+41.87%
1 Year Est. Return
+73.47%
3 Year Est. Return
+165.77%
5 Year Est. Return
+169.27%
10 Year Est. Return
+1,136.49%
AUM
$162M
AUM Growth
+$10.6M
Cap. Flow
-$25.2M
Cap. Flow %
-15.53%
Top 10 Hldgs %
35.02%
Holding
98
New
4
Increased
29
Reduced
28
Closed
16

Top Buys

Rank Stock Value
1
SI
Shoulder Innovations Inc
SI
+$6.01M
2
GPCR icon
Structure Therapeutics
GPCR
+$3.4M
3
XBI icon
State Street SPDR S&P Biotech ETF
XBI
+$3.06M
4
ANAB icon
AnaptysBio
ANAB
+$2.54M
5
TECX
Tectonic Therapeutic
TECX
+$1.94M

Top Sells

Rank Stock Value
1
LENZ
LENZ Therapeutics
LENZ
+$28.6M
2
MLYS icon
Mineralys Therapeutics
MLYS
+$7.54M
3
RAPP
Rapport Therapeutics
RAPP
+$2.43M
4
REPL icon
Replimune Group
REPL
+$2.15M
5
PVLA
Palvella Therapeutics
PVLA
+$2.07M

Sector Composition

Rank Sector Weight
1 Healthcare 97.9%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ONC
26
BeOne Medicines Ltd
ONC
$32.8B
$2.45M 1.51%
7,201
-515
-7% -$156K
ABT icon
27
Abbott
ABT
$183B
$2.3M 1.42%
17,198
+2,000
+13% +$263K
REGN icon
28
Regeneron Pharmaceuticals
REGN
$78.5B
$2.23M 1.38%
3,968
+1,195
+43% +$676K
GILD icon
29
Gilead Sciences
GILD
$162B
$2.17M 1.34%
19,550
-140
-0.7% -$15.9K
BSX icon
30
Boston Scientific
BSX
$69.5B
$2.16M 1.33%
22,126
+1,000
+5% +$104K
DHR icon
31
Danaher
DHR
$137B
$2.1M 1.3%
10,575
– –
PFE icon
32
Pfizer
PFE
$143B
$1.97M 1.21%
77,150
– –
INSM icon
33
Insmed
INSM
$21.4B
$1.93M 1.19%
13,425
-1,455
-10% -$178K
TMO icon
34
Thermo Fisher Scientific
TMO
$213B
$1.89M 1.17%
3,900
– –
QURE icon
35
uniQure
QURE
$3.03B
$1.79M 1.11%
30,740
-24,710
-45% -$449K
BNTX icon
36
BioNTech
BNTX
$22.9B
$1.74M 1.08%
17,660
+1,500
+9% +$160K
SYK icon
37
Stryker
SYK
$125B
$1.59M 0.98%
4,300
+400
+10% +$155K
SMMT icon
38
Summit Therapeutics
SMMT
$10.4B
$1.53M 0.94%
74,070
+8,850
+14% +$215K
ALNY icon
39
Alnylam Pharmaceuticals
ALNY
$27.5B
$1.49M 0.92%
3,273
-50
-2% -$20.4K
AZN icon
40
AstraZeneca
AZN
$263B
$1.44M 0.89%
9,375
+55
+0.6% +$8.32K
DXCM icon
41
DexCom
DXCM
$31.5B
$1.39M 0.86%
20,700
+7,500
+57% +$594K
MRK icon
42
Merck
MRK
$322B
$1.39M 0.86%
16,400
-4,500
-22% -$371K
BMRN icon
43
BioMarin Pharmaceuticals
BMRN
$11.6B
$1.36M 0.84%
25,030
+1,500
+6% +$85.8K
RAPP
44
Rapport Therapeutics
RAPP
$1.96B
$1.29M 0.8%
43,480
-136,380
-76% -$2.43M
MLYS icon
45
Mineralys Therapeutics
MLYS
$2.25B
$1.28M 0.79%
33,885
-348,530
-91% -$7.54M
SNDX icon
46
Syndax Pharmaceuticals
SNDX
$1.69B
$1.22M 0.75%
79,430
+16,130
+25% +$211K
EW icon
47
Edwards Lifesciences
EW
$49.6B
$1.17M 0.72%
15,000
– –
TARS icon
48
Tarsus Pharmaceuticals
TARS
$2.58B
$1.09M 0.68%
18,405
-130
-0.7% -$6.4K
MRUS
49
DELISTED
Merus
MRUS
$1.09M 0.67%
11,545
-4,130
-26% -$269K
TRVI icon
50
Trevi Therapeutics
TRVI
$2.59B
$969K 0.6%
105,950
-28,200
-21% -$211K
1
2
3 4

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Sectoral Asset Management's Q3 2025 Portfolio in Review

As of Q3 2025, Sectoral Asset Management held 98 positions worth $162M, up 7% from $151M the previous quarter. Its ten largest holdings account for 35% of the portfolio.

Sectoral Asset Management withdrew a net $25.2M in Q3 2025, closing 16 positions and reducing 28 holdings. Its most notable exit was LENZ Therapeutics, an estimated $28.6M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 98% of assets, down from 100% a quarter earlier.

Against the trend, Sectoral Asset Management opened a new position in Shoulder Innovations Inc worth $5.4M.

  • Sectoral Asset Management's largest Q3 2025 buy was Shoulder Innovations Inc: 430,282 shares worth $5.4M.
  • Sectoral Asset Management added most to Structure Therapeutics in Q3 2025, an estimated $3.4M increase.
  • Sectoral Asset Management's biggest Q3 2025 reduction was Mineralys Therapeutics, cutting an estimated $7.54M.
  • Sectoral Asset Management fully exited LENZ Therapeutics in Q3 2025, selling an estimated $28.6M.
  • Sectoral Asset Management's ten largest holdings make up 35% of its $162M portfolio in Q3 2025.
  • Sectoral Asset Management opened 4 new positions and closed 16 in Q3 2025.
  • Sectoral Asset Management's portfolio value rose 7% quarter-over-quarter to $162M.

Based on Sectoral Asset Management's 13F filing for Q3 2025, filed 14 Nov 2025.