Renaissance Technologies
SION

Renaissance Technologies’s Sionna Therapeutics SION Stock Holding History

Renaissance Technologies’s Portfolio SION Stock Details SION Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-14,600
Closed -$429K – 3905
2025
Q3 		$429K Sell
14,600
-11,400
-44% -$248K ﹤0.01% 2859
2025
Q2 		$451K Buy
+26,000
New +$341K ﹤0.01% 2887

Other funds holding SION

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGA
TPG GP A Fort Worth, Texas $3.68B AUM 14.99% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
Viking Global Investors
Viking Global Investors Stamford, Connecticut $35.7B AUM 21.3% 1-Year Est. Return
AVLSA
Atlas Venture Life Science Advisors Cambridge, Massachusetts $790M AUM 223.66% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return

Renaissance Technologies's SION Position: Q4 2025 in Review

Renaissance Technologies sold out of Sionna Therapeutics (SION) in Q4 2025, closing a stake of 14,600 shares — an estimated $429K sold.

Renaissance Technologies first reported a position in SION in Q2 2025 and held it in 2 quarters. The position peaked at $451K in Q2 2025. 101 funds tracked by Wall St. Rank hold SION as of Q4 2025.

  • Renaissance Technologies reported no remaining Sionna Therapeutics position as of Q4 2025 after selling out during the quarter.
  • Renaissance Technologies sold 14,600 Sionna Therapeutics shares in Q4 2025, an estimated $429K.
  • Renaissance Technologies first reported a position in Sionna Therapeutics in Q2 2025 and held it in 2 quarters.
  • Renaissance Technologies's Sionna Therapeutics position peaked at $451K in Q2 2025.
  • 101 funds tracked by Wall St. Rank held Sionna Therapeutics as of Q4 2025.

Based on Renaissance Technologies's 13F filing for Q4 2025, filed 12 Feb 2026.