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Opaleye Management Portfolio holdings

AUM $1.1B
1-Year Est. Return 197.64%
This Fund
S&P 500
This Quarter Est. Return
-2.21%
1 Year Est. Return
+197.64%
3 Year Est. Return
+748.31%
5 Year Est. Return
+1,163.14%
10 Year Est. Return
+87,953.74%
AUM
$170M
AUM Growth
-$21.4M
Cap. Flow
-$8.68M
Cap. Flow %
-5.12%
Top 10 Hldgs %
56.85%
Holding
56
New
12
Increased
10
Reduced
12
Closed
16

Top Buys

Rank Stock Value
1
TBPH icon
Theravance Biopharma
TBPH
+$4.91M
2
SBBP
Strongbridge Biopharma plc.
SBBP
+$4.73M
3
CLSD
Clearside Biomedical
CLSD
+$4.52M
4
MNTA
Momenta Pharmaceuticals, Inc.
MNTA
+$4.36M
5
BPMC
Blueprint Medicines
BPMC
+$2.86M

Top Sells

Rank Stock Value
1
CYNA
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR (CANADA)
CYNA
+$5.03M
2
HZNP
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
+$4.99M
3
GBT
Global Blood Therapeutics, Inc.
GBT
+$4.61M
4
IMMU
Immunomedics Inc
IMMU
+$3.9M
5
ZGNX
Zogenix, Inc.
ZGNX
+$2.52M

Sector Composition

Rank Sector Weight
1 Healthcare 99.49%
2 Miscellaneous 0.51%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
HZNP
51
DELISTED
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
– –
-275,000
Closed -$4.99M
INNL
52
DELISTED
Innocoll Holdings plc Ordinary Shares
INNL
– –
-269,100
Closed -$1.56M
CYNA
53
DELISTED
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR (CANADA)
CYNA
– –
-125,000
Closed -$5.03M
ZGNX
54
DELISTED
Zogenix, Inc.
ZGNX
– –
-220,000
Closed -$2.52M
1 2
3

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Opaleye Management's Q4 2016 Portfolio in Review

As of Q4 2016, Opaleye Management held 56 positions worth $170M, down 11% from $191M the previous quarter. Its ten largest holdings account for 57% of the portfolio.

Opaleye Management withdrew a net $8.68M in Q4 2016, closing 16 positions and reducing 12 holdings. Its most notable exit was CYNAPSUS THERAPEUTICS INC COM PAR NO PAR (CANADA), an estimated $5.03M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 99% of assets, up from 93% a quarter earlier, followed by Miscellaneous.

Against the trend, Opaleye Management opened a new position in Theravance Biopharma worth $5.04M.

  • Opaleye Management's largest Q4 2016 buy was Theravance Biopharma: 158,200 shares worth $5.04M.
  • Opaleye Management added most to Blueprint Medicines in Q4 2016, an estimated $2.86M increase.
  • Opaleye Management's biggest Q4 2016 reduction was Tvardi Therapeutics, cutting an estimated $1.78M.
  • Opaleye Management fully exited CYNAPSUS THERAPEUTICS INC COM PAR NO PAR (CANADA) in Q4 2016, selling an estimated $5.03M.
  • Opaleye Management's ten largest holdings make up 57% of its $170M portfolio in Q4 2016.
  • Opaleye Management opened 12 new positions and closed 16 in Q4 2016.
  • Opaleye Management's portfolio value fell 11% quarter-over-quarter to $170M.

Based on Opaleye Management's 13F filing for Q4 2016, filed 21 Feb 2017.