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Opaleye Management Portfolio holdings

AUM $1.1B
1-Year Est. Return 197.64%
This Fund
S&P 500
This Quarter Est. Return
-1.03%
1 Year Est. Return
+197.64%
3 Year Est. Return
+748.31%
5 Year Est. Return
+1,163.14%
10 Year Est. Return
+87,953.74%
AUM
$438M
AUM Growth
-$21.2M
Cap. Flow
+$25.3M
Cap. Flow %
5.78%
Top 10 Hldgs %
58.99%
Holding
62
New
9
Increased
15
Reduced
17
Closed
11

Top Buys

Rank Stock Value
1
IMNM icon
Immunome
IMNM
+$17.2M
2
CYTK icon
Cytokinetics
CYTK
+$12M
3
CRGX
CARGO Therapeutics
CRGX
+$10.6M
4
JBIO
Jade Biosciences
JBIO
+$8.34M
5
ARVN icon
Arvinas
ARVN
+$7.17M

Top Sells

Rank Stock Value
1
CRNX icon
Crinetics Pharmaceuticals
CRNX
+$9.83M
2
OCUL icon
Ocular Therapeutix
OCUL
+$8.31M
3
CMPX icon
Compass Therapeutics
CMPX
+$6.28M
4
CPRX
Catalyst Pharmaceutical
CPRX
+$5.67M
5
NYXH
Nyxoah
NYXH
+$4.32M

Sector Composition

Rank Sector Weight
1 Healthcare 98.24%
2 Miscellaneous 1.76%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
TARA icon
26
Protara Therapeutics
TARA
$236M
$5.3M 1.21%
2,304,262
-388,332
-14% -$1.14M
NTLA icon
27
Intellia Therapeutics
NTLA
$1.84B
$4.88M 1.11%
218,000
-37,000
-15% -$881K
NUVL
28
DELISTED
Nuvalent
NUVL
$4.5M 1.03%
+59,300
New +$4.22M
SYRS
29
DELISTED
Syros Pharmaceuticals, Inc. Common Stock
SYRS
$4.47M 1.02%
865,443
+77,898
+10% +$409K
LQDA icon
30
Liquidia Corp
LQDA
$6.26B
$3.9M 0.89%
325,000
-70,000
-18% -$929K
PTGX icon
31
Protagonist Therapeutics
PTGX
$9.67B
$3.64M 0.83%
105,000
-7,700
-7% -$226K
GOSS icon
32
Gossamer Bio
GOSS
$83.2M
$3.52M 0.8%
3,910,000
+1,469,891
+60% +$1.1M
LXRX icon
33
Lexicon Pharmaceuticals
LXRX
$1.03B
$3.15M 0.72%
+1,875,000
New +$3.36M
SVRA icon
34
Savara
SVRA
$1.13B
$2.88M 0.66%
714,960
-140,040
-16% -$623K
ALLK
35
DELISTED
Allakos
ALLK
$2.78M 0.64%
2,780,000
+345,000
+14% +$410K
VTYX
36
DELISTED
Ventyx Biosciences
VTYX
$2.75M 0.63%
1,190,000
-95,000
-7% -$395K
VSTM icon
37
Verastem
VSTM
$668M
$2.73M 0.62%
915,000
+703,600
+333% +$5.8M
RGLS
38
DELISTED
Regulus Therapeutics
RGLS
$2.63M 0.6%
1,475,000
+1,304,692
+766% +$3.03M
LYEL icon
39
Lyell Immunopharma
LYEL
$358M
$2.42M 0.55%
83,500
-84,250
-50% -$4.01M
RLMD icon
40
Relmada Therapeutics
RLMD
$482M
$1.8M 0.41%
600,000
-159,000
-21% -$575K
FULC icon
41
Fulcrum Therapeutics
FULC
$294M
$1.77M 0.4%
285,000
+155,000
+119% +$1.17M
KPTI icon
42
Karyopharm Therapeutics
KPTI
$44M
$1.24M 0.28%
+95,000
New +$1.57M
IBIO icon
43
iBio
IBIO
$69.5M
$791K 0.18%
375,000
-305,000
-45% -$656K
PMVP icon
44
PMV Pharmaceuticals
PMVP
$66.3M
$770K 0.18%
475,000
+3,519
+0.7% +$6.35K
JBIO
45
Jade Biosciences
JBIO
$1.35B
$730K 0.17%
+12,571
New +$8.34M
DSGN icon
46
Design Therapeutics
DSGN
$954M
$687K 0.16%
205,000
+91,962
+81% +$358K
ABCL icon
47
AbCellera Biologics
ABCL
$4.02B
$592K 0.14%
+200,000
New +$757K
ALGS icon
48
Aligos Therapeutics
ALGS
$44.1M
$441K 0.1%
50,400
-14,800
-23% -$260K
OKUR
49
OnKure Therapeutics
OKUR
$155M
$249K 0.06%
+16,500
New +$280K
CMPX icon
50
Compass Therapeutics
CMPX
$454M
– –
-3,170,000
Closed -$6.28M
1
2
3

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HBCM
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Opaleye Management's Q2 2024 Portfolio in Review

As of Q2 2024, Opaleye Management held 62 positions worth $438M, down 4.6% from $459M the previous quarter. Its ten largest holdings account for 59% of the portfolio.

Opaleye Management deployed $25.3M of net new capital in Q2 2024, opening 9 new positions and adding to 15 existing holdings. Its largest new stake was Immunome: 1,102,500 shares worth $13.3M.

By sector, the portfolio is most concentrated in Healthcare at 98% of assets, down from 99% a quarter earlier, followed by Miscellaneous.

On the sell side, the largest reduction was Ocular Therapeutix, an estimated $8.31M trimmed.

  • Opaleye Management's largest Q2 2024 buy was Immunome: 1,102,500 shares worth $13.3M.
  • Opaleye Management added most to Arvinas in Q2 2024, an estimated $7.17M increase.
  • Opaleye Management's biggest Q2 2024 reduction was Ocular Therapeutix, cutting an estimated $8.31M.
  • Opaleye Management fully exited Crinetics Pharmaceuticals in Q2 2024, selling an estimated $9.83M.
  • Opaleye Management's ten largest holdings make up 59% of its $438M portfolio in Q2 2024.
  • Opaleye Management opened 9 new positions and closed 11 in Q2 2024.
  • Opaleye Management's portfolio value fell 4.6% quarter-over-quarter to $438M.

Based on Opaleye Management's 13F filing for Q2 2024, filed 14 Aug 2024.