OM

Opaleye Management Portfolio holdings

AUM $494M
This Quarter Return
+14.09%
1 Year Return
+68.17%
3 Year Return
+608.37%
5 Year Return
+807.76%
10 Year Return
+24,567.28%
AUM
$328M
AUM Growth
+$328M
Cap. Flow
-$47.8M
Cap. Flow %
-14.57%
Top 10 Hldgs %
48.5%
Holding
63
New
10
Increased
14
Reduced
12
Closed
20

Top Buys

1
LXRX icon
Lexicon Pharmaceuticals
LXRX
$9.31M
2
BHVN
Biohaven Pharmaceutical Holding Company Ltd.
BHVN
$6.57M
3
IRWD icon
Ironwood Pharmaceuticals
IRWD
$5.75M
4
ARVN icon
Arvinas
ARVN
$4.84M
5
OCUL icon
Ocular Therapeutix
OCUL
$4.62M

Top Sells

1
ASND icon
Ascendis Pharma
ASND
$11.2M
2
CMTA
Clementia Pharmaceuticals Inc.
CMTA
$10.4M
3
NVTA
Invitae Corporation
NVTA
$10.3M
4
CPRX icon
Catalyst Pharmaceutical
CPRX
$9.31M
5
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
$7.7M

Sector Composition

1 Healthcare 98.09%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
IRWD icon
26
Ironwood Pharmaceuticals
IRWD
$201M
$5.75M 1.75%
+525,400
New +$5.75M
ACAD icon
27
Acadia Pharmaceuticals
ACAD
$4.34B
$5.35M 1.63%
200,000
– –
ARVN icon
28
Arvinas
ARVN
$580M
$4.84M 1.47%
+220,000
New +$4.84M
VRML
29
DELISTED
Vermillion, Inc.
VRML
$3.78M 1.15%
+4,250,000
New +$3.78M
ZYME icon
30
Zymeworks
ZYME
$1.07B
$3.74M 1.14%
170,000
+115,000
+209% +$2.53M
SBBP
31
DELISTED
Strongbridge Biopharma plc.
SBBP
$3.57M 1.09%
1,140,000
-12,500
-1% -$39.1K
VKTX icon
32
Viking Therapeutics
VKTX
$3.02B
$3.32M 1.01%
400,000
-85,000
-18% -$706K
AIMT
33
DELISTED
Aimmune Therapeutics, Inc.
AIMT
$2.71M 0.83%
130,000
-35,000
-21% -$729K
AQST icon
34
Aquestive Therapeutics
AQST
$478M
$2.48M 0.76%
+590,000
New +$2.48M
THOR
35
DELISTED
Synthorx, Inc. Common Stock
THOR
$2.13M 0.65%
157,600
+117,600
+294% +$1.59M
RARX
36
DELISTED
Ra Pharmaceuticals, Inc. Common Stock
RARX
$1.53M 0.47%
+51,000
New +$1.53M
FENC icon
37
Fennec Pharmaceuticals
FENC
$247M
$1.18M 0.36%
295,000
-335,000
-53% -$1.34M
ARQL
38
DELISTED
Arqule Inc
ARQL
$1.1M 0.34%
+100,000
New +$1.1M
CRNX icon
39
Crinetics Pharmaceuticals
CRNX
$3.26B
$900K 0.27%
36,000
-37,000
-51% -$925K
PLX icon
40
Protalix BioTherapeutics
PLX
$128M
$469K 0.14%
+1,000,000
New +$469K
ENTO
41
Entero Therapeutics
ENTO
$4.4M
$247K 0.08%
+145,000
New +$247K
BLRX
42
BioLineRX
BLRX
$15.5M
$91K 0.03%
250,000
– –
LJPC
43
DELISTED
La Jolla Pharmaceutical Company
LJPC
– –
-60,000
Closed -$386K
CMTA
44
DELISTED
Clementia Pharmaceuticals Inc.
CMTA
– –
-400,130
Closed -$10.4M
HZNP
45
DELISTED
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
– –
-185,000
Closed -$4.89M
DERM
46
DELISTED
Dermira, Inc.
DERM
– –
-400,000
Closed -$5.42M
FOMX
47
DELISTED
Foamix Pharmaceuticals Ltd. Ordinary Shares
FOMX
– –
-180,000
Closed -$675K
ACOR
48
DELISTED
Acorda Therapeutics, Inc.
ACOR
– –
-265,000
Closed -$3.52M
MRTX
49
DELISTED
Mirati Therapeutics, Inc. Common Stock
MRTX
– –
-105,000
Closed -$7.7M
NVTA
50
DELISTED
Invitae Corporation
NVTA
– –
-440,000
Closed -$10.3M
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