Jane Street
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Jane Street’s Spero Therapeutics SPRO Stock Holding History

Jane Street’s Portfolio SPRO Stock Details SPRO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$59.2K Sell
26,800
-11,700
-30% -$30.6K ﹤0.01% 10862
2026
Q1 		$90.1K Sell
38,500
-100
-0.3% -$237 ﹤0.01% 10698
2025
Q4 		$89.9K Buy
+38,600
New +$89.6K ﹤0.01% 10235

Other funds holding SPRO

GP
GSK plc London $602M AUM
P
Pfizer New York $170M AUM 191.09% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Renaissance Technologies
Renaissance Technologies New York $72.6B AUM 54.88% 1-Year Est. Return
AI
Alphabet Inc Mountain View, California $99.1B AUM 124.46% 1-Year Est. Return
Susquehanna International Group
Susquehanna International Group Bala Cynwyd, Pennsylvania $1.28T AUM 58.89% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.88T AUM 44.46% 1-Year Est. Return
Raymond James Financial
Raymond James Financial St Petersburg, Florida $369B AUM 28.27% 1-Year Est. Return
Two Sigma Investments
Two Sigma Investments New York $138B AUM 41.87% 1-Year Est. Return

Jane Street's SPRO Position: Q2 2026 in Review

Jane Street increased its Spero Therapeutics (SPRO) stake by 49% in Q2 2026, buying an estimated $135K and bringing the position to 158,097 shares worth $349K. The position accounts for ﹤0.01% of the portfolio, ranked #8867.

Jane Street first reported a position in SPRO in Q1 2021 and has held it in 8 quarters since. The position peaked at $369K in Q4 2025. 59 funds tracked by Wall St. Rank hold SPRO as of Q2 2026.

  • Jane Street held 158,097 shares of Spero Therapeutics worth $349K as of Q2 2026.
  • Jane Street bought 51,752 Spero Therapeutics shares in Q2 2026, an estimated $135K.
  • Spero Therapeutics made up ﹤0.01% of Jane Street's portfolio in Q2 2026, its #8867 holding.
  • Jane Street first reported a position in Spero Therapeutics in Q1 2021 and has held it in 8 quarters since.
  • Jane Street's Spero Therapeutics position peaked at $369K in Q4 2025.
  • 59 funds tracked by Wall St. Rank held Spero Therapeutics as of Q2 2026.

Based on Jane Street's 13F filing for Q2 2026, filed 14 Aug 2026.