Jane Street’s OptimizeRx OPRX Stock Holding History

Jane Street’s Portfolio OPRX Stock Details OPRX Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	–	Sell	-87,481	Closed	-$812K	–	12601
2025 Q4	$1.07M	Buy	+87,481	New	+$1.43M	﹤0.01%	5977
2025 Q1	–	Sell	-72,454	Closed	-$443K	–	10284
2024 Q4	$352K	Buy	72,454 +50,808	+235%	+$284K	﹤0.01%	7465
2024 Q3	$167K	Sell	21,646 -12,682	-37%	-$113K	﹤0.01%	8757
2024 Q2	$343K	Buy	34,328 +6,173	+22%	+$67.8K	﹤0.01%	7590
2024 Q1	$342K	Buy	+28,155	New	+$408K	﹤0.01%	7341
2023 Q2	–	Sell	-126,652	Closed	-$1.85M	–	9314
2023 Q1	$1.85M	Buy	+126,652	New	+$2.12M	﹤0.01%	3962
2022 Q2	–	Sell	-15,299	Closed	-$453K	–	10520
2022 Q1	$577K	Buy	15,299 +10,623	+227%	+$470K	﹤0.01%	7195
2021 Q4	$290K	Sell	4,676 -7,503	-62%	-$569K	﹤0.01%	8226
2021 Q3	$1.04M	Buy	12,179 +3,770	+45%	+$237K	﹤0.01%	5824
2021 Q2	$521K	Sell	8,409 -3,383	-29%	-$172K	﹤0.01%	7158
2021 Q1	$575K	Buy	+11,792	New	+$569K	﹤0.01%	6551

Other funds holding OPRX

WCA

Whetstone Capital Advisors Shawnee Mission, Kansas $288M AUM 44.06% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

Royce & Associates New York $10.1B AUM 42.88% 1-Year Est. Return

PHP

Parkman Healthcare Partners Stamford, Connecticut $970M AUM 79.46% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

KCM

Kennedy Capital Management St Louis, Missouri $4.72B AUM 36.69% 1-Year Est. Return

William Blair & Company Chicago, Illinois $34.9B AUM 18.88% 1-Year Est. Return

RHJA

Rice Hall James & Associates San Diego, California $1.8B AUM 36.16% 1-Year Est. Return

Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return

State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Jane Street's OPRX Position: Q1 2026 in Review

Jane Street sold out of OptimizeRx (OPRX) in Q1 2026, closing a stake of 87,481 shares — an estimated $812K sold.

Jane Street first reported a position in OPRX in Q1 2021 and held it in 11 quarters. The position peaked at $1.85M in Q1 2023. 128 funds tracked by Wall St. Rank hold OPRX as of Q1 2026.

Jane Street reported no remaining OptimizeRx position as of Q1 2026 after selling out during the quarter.
Jane Street sold 87,481 OptimizeRx shares in Q1 2026, an estimated $812K.
Jane Street first reported a position in OptimizeRx in Q1 2021 and held it in 11 quarters.
Jane Street's OptimizeRx position peaked at $1.85M in Q1 2023.
128 funds tracked by Wall St. Rank held OptimizeRx as of Q1 2026.

Based on Jane Street's 13F filing for Q1 2026, filed 12 May 2026.