Jane Street’s Definium Therapeutics DFTX Stock Holding History

Jane Street’s Portfolio DFTX Stock Details DFTX Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$652K	Sell	34,500 -1,000	-3%	-$17K	﹤0.01%	7417
2025 Q4	$475K	Buy	35,500 +7,200	+25%	+$89.1K	﹤0.01%	7806
2025 Q3	$334K	Buy	+28,300	New	+$264K	﹤0.01%	8697
2024 Q2	–	Sell	-38,400	Closed	-$361K	–	9888
2024 Q1	$361K	Buy	+38,400	New	+$219K	﹤0.01%	7255
2023 Q1	–	Sell	-17,347	Closed	-$38.2K	–	9579
2022 Q4	$38.2K	Sell	17,347 -59,527	-77%	-$165K	﹤0.01%	8447
2022 Q3	$267K	Buy	+76,874	New	+$738K	﹤0.01%	7765
2022 Q2	–	Sell	-1,053	Closed	-$18K	–	10420
2022 Q1	$18K	Sell	1,053 -2,087	-66%	-$36.2K	﹤0.01%	9966
2021 Q4	$65K	Sell	3,140 -4,607	-59%	-$147K	﹤0.01%	9430
2021 Q3	$280K	Buy	+7,747	New	+$335K	﹤0.01%	8324

Other funds holding DFTX

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return

ACA

Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return

DTC

Deep Track Capital Greenwich, Connecticut $6.12B AUM 144% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

OCA

Octagon Capital Advisors New York $904M AUM 737.04% 1-Year Est. Return

Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

Jane Street's DFTX Position: Q1 2026 in Review

Jane Street reduced its Definium Therapeutics (DFTX) stake by 51% in Q1 2026, selling an estimated $4.68M and leaving 260,241 shares worth $4.92M. The position accounts for ﹤0.01% of the portfolio, ranked #3548.

Jane Street first reported a position in DFTX in Q2 2021 and has held it in 17 quarters since. The position peaked at $7.18M in Q4 2025. 247 funds tracked by Wall St. Rank hold DFTX as of Q1 2026.

Jane Street held 260,241 shares of Definium Therapeutics worth $4.92M as of Q1 2026.
Jane Street sold 275,761 Definium Therapeutics shares in Q1 2026, an estimated $4.68M.
Definium Therapeutics made up ﹤0.01% of Jane Street's portfolio in Q1 2026, its #3548 holding.
Jane Street first reported a position in Definium Therapeutics in Q2 2021 and has held it in 17 quarters since.
Jane Street's Definium Therapeutics position peaked at $7.18M in Q4 2025.
247 funds tracked by Wall St. Rank held Definium Therapeutics as of Q1 2026.

Based on Jane Street's 13F filing for Q1 2026, filed 12 May 2026.