Jane Street’s Castle Biosciences CSTL Stock Holding History

Jane Street’s Portfolio CSTL Stock Details CSTL Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	–	Sell	-22,800	Closed	-$560K	–	11772
2026 Q1	$560K	Buy	22,800 +13,500	+145%	+$442K	﹤0.01%	7785
2025 Q4	$362K	Sell	9,300 -8,600	-48%	-$277K	﹤0.01%	8413
2025 Q3	$408K	Buy	+17,900	New	+$364K	﹤0.01%	8283
2024 Q4	–	Sell	-11,100	Closed	-$317K	–	9551
2024 Q3	$317K	Sell	11,100 -18,900	-63%	-$481K	﹤0.01%	7935
2024 Q2	$653K	Sell	30,000 -23,500	-44%	-$524K	﹤0.01%	6583
2024 Q1	$1.19M	Buy	+53,500	New	+$1.16M	﹤0.01%	5098

Other funds holding CSTL

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return

Principal Financial Group Des Moines, Iowa $204B AUM 27.99% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

Acadian Asset Management Boston, Massachusetts $84.2B AUM 55.88% 1-Year Est. Return

Allianz Asset Management Munich, Germany $123B AUM 45.23% 1-Year Est. Return

Vanguard Portfolio Management Malvern, Pennsylvania $2.22T AUM

SPPAM

Summit Partners Public Asset Management Boston, Massachusetts $5.69B AUM 259.25% 1-Year Est. Return

State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.88T AUM 44.46% 1-Year Est. Return

Jane Street's CSTL Position: Q2 2026 in Review

Jane Street increased its Castle Biosciences (CSTL) stake by 5.2% in Q2 2026, buying an estimated $49.7K and bringing the position to 44,793 shares worth $1.07M. The position accounts for ﹤0.01% of the portfolio, ranked #6409.

Jane Street first reported a position in CSTL in Q2 2020 and has held it in 17 quarters since. The position peaked at $6.56M in Q4 2025. 177 funds tracked by Wall St. Rank hold CSTL as of Q2 2026.

Jane Street held 44,793 shares of Castle Biosciences worth $1.07M as of Q2 2026.
Jane Street bought 2,231 Castle Biosciences shares in Q2 2026, an estimated $49.7K.
Castle Biosciences made up ﹤0.01% of Jane Street's portfolio in Q2 2026, its #6409 holding.
Jane Street first reported a position in Castle Biosciences in Q2 2020 and has held it in 17 quarters since.
Jane Street's Castle Biosciences position peaked at $6.56M in Q4 2025.
177 funds tracked by Wall St. Rank held Castle Biosciences as of Q2 2026.

Based on Jane Street's 13F filing for Q2 2026, filed 14 Aug 2026.