Jane Street
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Jane Street’s Castle Biosciences CSTL Stock Holding History

Jane Street’s Portfolio CSTL Stock Details CSTL Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$1.04M Sell
42,562
-126,084
-75% -$4.13M ﹤0.01% 6399
2025
Q4 		$6.56M Buy
168,646
+145,762
+637% +$4.7M ﹤0.01% 2845
2025
Q3 		$521K Buy
+22,884
New +$465K ﹤0.01% 7779
2025
Q2 		– Sell
-30,676
Closed -$614K – 9791
2025
Q1 		$614K Sell
30,676
-28,707
-48% -$711K ﹤0.01% 6483
2024
Q4 		$1.58M Sell
59,383
-74,901
-56% -$2.28M ﹤0.01% 4538
2024
Q3 		$3.83M Buy
134,284
+97,260
+263% +$2.48M ﹤0.01% 3294
2024
Q2 		$806K Buy
+37,024
New +$825K ﹤0.01% 6193
2024
Q1 		– Sell
-43,351
Closed -$943K – 9315
2023
Q4 		$936K Buy
43,351
+22,560
+109% +$397K ﹤0.01% 5682
2023
Q3 		$351K Sell
20,791
-2,371
-10% -$41.5K ﹤0.01% 6824
2023
Q2 		$318K Buy
+23,162
New +$469K ﹤0.01% 7032
2022
Q2 		– Sell
-7,660
Closed -$344K – 9787
2022
Q1 		$344K Buy
+7,660
New +$317K ﹤0.01% 8179
2021
Q4 		– Sell
-16,423
Closed -$1.09M – 10157
2021
Q3 		$1.09M Buy
+16,423
New +$1.16M ﹤0.01% 5742
2021
Q2 		– Sell
-18,210
Closed -$1.25M – 9844
2021
Q1 		$1.25M Buy
18,210
+4,121
+29% +$310K ﹤0.01% 5025
2020
Q4 		$946K Buy
14,089
+2,977
+27% +$161K ﹤0.01% 4752
2020
Q3 		$572K Buy
11,112
+4,370
+65% +$194K ﹤0.01% 4943
2020
Q2 		$255K Buy
+6,742
New +$230K ﹤0.01% 6071

Other funds holding CSTL

BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
Principal Financial Group
Principal Financial Group Des Moines, Iowa $187B AUM 18.48% 1-Year Est. Return
PCM
Portolan Capital Management Boston, Massachusetts $1.88B AUM 115.74% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return
SPPAM
Summit Partners Public Asset Management Boston, Massachusetts $3.72B AUM 162.29% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
Allianz Asset Management
Allianz Asset Management Munich, Germany $95.4B AUM 38.74% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Jane Street's CSTL Position: Q1 2026 in Review

Jane Street reduced its Castle Biosciences (CSTL) stake by 75% in Q1 2026, selling an estimated $4.13M and leaving 42,562 shares worth $1.04M. The position accounts for ﹤0.01% of the portfolio, ranked #6399.

Jane Street first reported a position in CSTL in Q2 2020 and has held it in 16 quarters since. The position peaked at $6.56M in Q4 2025. 186 funds tracked by Wall St. Rank hold CSTL as of Q1 2026.

  • Jane Street held 42,562 shares of Castle Biosciences worth $1.04M as of Q1 2026.
  • Jane Street sold 126,084 Castle Biosciences shares in Q1 2026, an estimated $4.13M.
  • Castle Biosciences made up ﹤0.01% of Jane Street's portfolio in Q1 2026, its #6399 holding.
  • Jane Street first reported a position in Castle Biosciences in Q2 2020 and has held it in 16 quarters since.
  • Jane Street's Castle Biosciences position peaked at $6.56M in Q4 2025.
  • 186 funds tracked by Wall St. Rank held Castle Biosciences as of Q1 2026.

Based on Jane Street's 13F filing for Q1 2026, filed 12 May 2026.