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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
IDXX icon
201
Idexx Laboratories
IDXX
$45B
$10.9K 0.01%
17
– –
ROST icon
202
Ross Stores
ROST
$79.6B
$10.8K 0.01%
71
– –
STX icon
203
Seagate
STX
$199B
$10.6K 0.01%
45
– –
WBD icon
204
Warner Bros
WBD
$69.3B
$10.4K 0.01%
531
+50
+10% +$681
BKR icon
205
Baker Hughes
BKR
$63.8B
$10.3K 0.01%
212
-1
-0.5% -$44
MNST icon
206
Monster Beverage
MNST
$90.1B
$10.3K 0.01%
306
+4
+1% +$125
CARR icon
207
Carrier Global
CARR
$52B
$10.3K 0.01%
172
-2
-1% -$136
XEL icon
208
Xcel Energy
XEL
$49.1B
$10.2K 0.01%
127
+3
+2% +$217
DHI icon
209
D.R. Horton
DHI
$40.8B
$10.2K 0.01%
60
-1
-2% -$157
F icon
210
Ford
F
$55.1B
$10K 0.01%
840
-3
-0.4% -$35
CBRE icon
211
CBRE Group
CBRE
$42.7B
$9.93K 0.01%
63
– –
MET icon
212
MetLife
MET
$61.4B
$9.88K 0.01%
120
-5
-4% -$393
EA
213
DELISTED
Electronic Arts
EA
$9.88K 0.01%
49
-2
-4% -$331
EW icon
214
Edwards Lifesciences
EW
$53.6B
$9.88K 0.01%
127
– –
CTVA icon
215
Corteva
CTVA
$50.4B
$9.87K 0.01%
146
-2
-1% -$145
RSG icon
216
Republic Services
RSG
$65.6B
$9.87K 0.01%
43
– –
OKE icon
217
Oneok
OKE
$58.3B
$9.85K 0.01%
135
+1
+0.7% +$77
DDOG icon
218
Datadog
DDOG
$86.5B
$9.83K 0.01%
+69
New +$9.5K
AMP icon
219
Ameriprise Financial
AMP
$49.9B
$9.82K 0.01%
20
– –
PSA icon
220
Public Storage
PSA
$60.4B
$9.82K 0.01%
34
– –
EXC icon
221
Exelon
EXC
$46.6B
$9.77K 0.01%
217
– –
TTWO icon
222
Take-Two Interactive
TTWO
$45.4B
$9.56K 0.01%
37
+1
+3% +$237
DELL icon
223
Dell
DELL
$313B
$9.36K 0.01%
66
-1
-1% -$130
AIG icon
224
American International
AIG
$39.8B
$9.35K 0.01%
119
-9
-7% -$719
AME icon
225
Ametek
AME
$59.3B
$9.21K 0.01%
49
– –
7 8
9
10 11

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VM
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SSC
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ACM
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MCM
Millstreet Capital Management Boston, Massachusetts $418M AUM 80.77% 1-Year Est. Return
MIA
Milestone Investment Advisors Middleton, Wisconsin $414M AUM 12.76% 1-Year Est. Return
SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.