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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
GM icon
176
General Motors
GM
$76.1B
$12.5K 0.01%
205
-10
-5% -$558
REGN icon
177
Regeneron Pharmaceuticals
REGN
$82.2B
$12.4K 0.01%
22
– –
NXPI icon
178
NXP Semiconductors
NXPI
$58.9B
$12.3K 0.01%
54
– –
CMI icon
179
Cummins
CMI
$87.8B
$12.2K 0.01%
29
– –
ALL icon
180
Allstate
ALL
$64.7B
$12.2K 0.01%
57
– –
LHX icon
181
L3Harris
LHX
$54.1B
$12.2K 0.01%
40
– –
FCX icon
182
Freeport-McMoran
FCX
$96.9B
$12.1K 0.01%
309
-1
-0.3% -$43
FAST icon
183
Fastenal
FAST
$59.9B
$12.1K 0.01%
246
– –
O icon
184
Realty Income
O
$59.2B
$11.9K 0.01%
196
+7
+4% +$408
KMI icon
185
Kinder Morgan
KMI
$70.7B
$11.9K 0.01%
419
+2
+0.5% +$55
PSX icon
186
Phillips 66
PSX
$90B
$11.8K 0.01%
87
-2
-2% -$256
DLR icon
187
Digital Realty Trust
DLR
$72.9B
$11.8K 0.01%
68
– –
FTNT icon
188
Fortinet
FTNT
$118B
$11.7K 0.01%
139
+2
+1% +$178
AFL icon
189
Aflac
AFL
$60.5B
$11.6K 0.01%
104
-2
-2% -$210
BDX icon
190
Becton Dickinson
BDX
$50B
$11.6K 0.01%
62
– –
AXON
191
Axon Enterprise
AXON
$48.7B
$11.5K 0.01%
16
+1
+7% +$759
ROP icon
192
Roper Technologies
ROP
$39.1B
$11.5K 0.01%
23
– –
VLO icon
193
Valero Energy
VLO
$95.1B
$11.4K 0.01%
67
-1
-1% -$149
ABNB icon
194
Airbnb
ABNB
$108B
$11.3K 0.01%
93
– –
CMG icon
195
Chipotle Mexican Grill
CMG
$41.3B
$11.3K 0.01%
288
-4
-1% -$180
D icon
196
Dominion Energy
D
$59.8B
$11.2K 0.01%
183
+2
+1% +$119
PCAR icon
197
PACCAR
PCAR
$69B
$11.1K 0.01%
113
– –
FDX icon
198
FedEx
FDX
$77.3B
$11.1K 0.01%
47
– –
WDAY icon
199
Workday
WDAY
$43.3B
$11.1K 0.01%
46
– –
SLB icon
200
SLB Ltd
SLB
$78.1B
$11K 0.01%
320
+18
+6% +$626
6 7
8
9 10

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MCM
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.