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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ADSK icon
151
Autodesk
ADSK
$52.7B
$14.6K 0.01%
46
– –
NSC icon
152
Norfolk Southern
NSC
$75.3B
$14.4K 0.01%
48
– –
CSX icon
153
CSX Corp
CSX
$92.8B
$14.2K 0.01%
401
-15
-4% -$512
TEL icon
154
TE Connectivity
TEL
$62B
$14.1K 0.01%
64
– –
ZTS icon
155
Zoetis
ZTS
$30.4B
$14K 0.01%
96
– –
CL icon
156
Colgate-Palmolive
CL
$73.6B
$13.9K 0.01%
174
-1
-0.6% -$85
PYPL icon
157
PayPal
PYPL
$50.6B
$13.8K 0.01%
206
-7
-3% -$493
GLW icon
158
Corning
GLW
$144B
$13.7K 0.01%
167
+1
+0.6% +$65
TRV icon
159
Travelers Companies
TRV
$77.2B
$13.7K 0.01%
49
– –
VST icon
160
Vistra
VST
$49.2B
$13.5K 0.01%
69
-4
-5% -$793
URI icon
161
United Rentals
URI
$70.3B
$13.4K 0.01%
14
– –
HLT icon
162
Hilton Worldwide
HLT
$72.6B
$13.2K 0.01%
51
– –
EOG icon
163
EOG Resources
EOG
$75.1B
$13.2K 0.01%
118
-3
-2% -$358
UPS icon
164
United Parcel Service
UPS
$88.4B
$13.2K 0.01%
158
– –
SPG icon
165
Simon Property Group
SPG
$71.4B
$13.1K 0.01%
70
+4
+6% +$691
APD icon
166
Air Products & Chemicals
APD
$67.7B
$13.1K 0.01%
48
– –
APO icon
167
Apollo Global Management
APO
$81.9B
$13.1K 0.01%
98
+2
+2% +$283
AEP icon
168
American Electric Power
AEP
$67.9B
$12.9K 0.01%
115
– –
AZO icon
169
AutoZone
AZO
$49.7B
$12.9K 0.01%
3
– –
PWR icon
170
Quanta Services
PWR
$102B
$12.8K 0.01%
31
– –
COR icon
171
Cencora
COR
$60B
$12.8K 0.01%
41
+4
+11% +$1.18K
MAR icon
172
Marriott International
MAR
$92.5B
$12.8K 0.01%
49
– –
MPC icon
173
Marathon Petroleum
MPC
$97.8B
$12.7K 0.01%
66
-2
-3% -$352
TFC icon
174
Truist Financial
TFC
$64.3B
$12.7K 0.01%
277
-7
-2% -$316
SRE icon
175
Sempra
SRE
$56.2B
$12.6K 0.01%
140
+4
+3% +$324
5 6
7
8 9

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ACM
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MCM
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MIA
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.