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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+2.49%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$175M
AUM Growth
+$4.07M
Cap. Flow
+$32K
Cap. Flow %
0.02%
Top 10 Hldgs %
95.56%
Holding
506
New
6
Increased
70
Reduced
86
Closed
6

Top Buys

Rank Stock Value
1
CRH icon
CRH
CRH
+$17.2K
2
CVNA icon
Carvana
CVNA
+$11.2K
3
ARES icon
Ares Management
ARES
+$6.86K
4
FIX icon
Comfort Systems
FIX
+$6.46K
5
SNDK
Sandisk
SNDK
+$6.01K

Top Sells

Rank Stock Value
1
K
Kellanova
K
+$4.76K
2
DD icon
DuPont de Nemours
DD
+$4.72K
3
NVDA icon
NVIDIA
NVDA
+$3.54K
4
IPG
Interpublic Group of Companies
IPG
+$2.21K
5
LKQ icon
LKQ Corp
LKQ
+$1.71K

Sector Composition

Rank Sector Weight
1 Technology 2.52%
2 Financials 0.95%
3 Communication Services 0.78%
4 Consumer Discretionary 0.76%
5 Healthcare 0.69%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ADBE icon
76
Adobe
ADBE
$103B
$31.8K 0.02%
91
-1
-1% -$340
DHR icon
77
Danaher
DHR
$145B
$31.1K 0.02%
136
-1
-0.7% -$220
PFE icon
78
Pfizer
PFE
$150B
$30.5K 0.02%
1,226
+5
+0.4% +$126
BSX icon
79
Boston Scientific
BSX
$74.5B
$30.4K 0.02%
319
+1
+0.3% +$98
UNP icon
80
Union Pacific
UNP
$174B
$29.6K 0.02%
128
– –
LOW icon
81
Lowe's Companies
LOW
$121B
$29.2K 0.02%
121
– –
ANET icon
82
Arista Networks
ANET
$265B
$29.1K 0.02%
222
– –
ADI icon
83
Analog Devices
ADI
$187B
$28.7K 0.02%
106
-1
-0.9% -$251
PGR icon
84
Progressive
PGR
$121B
$28.7K 0.02%
126
– –
WELL icon
85
Welltower
WELL
$166B
$27.3K 0.02%
147
+4
+3% +$747
PANW icon
86
Palo Alto Networks
PANW
$315B
$27.1K 0.02%
147
+4
+3% +$807
ETN icon
87
Eaton
ETN
$179B
$26.8K 0.02%
84
– –
HON icon
88
Honeywell
HON
$74.6B
$26.7K 0.02%
137
-8
-6% -$1.56K
MDT icon
89
Medtronic
MDT
$116B
$26.5K 0.02%
276
– –
SYK icon
90
Stryker
SYK
$133B
$26K 0.01%
74
– –
PLD icon
91
Prologis
PLD
$134B
$25.5K 0.01%
200
– –
DE icon
92
Deere & Co
DE
$167B
$25.1K 0.01%
54
– –
COP icon
93
ConocoPhillips
COP
$153B
$25K 0.01%
267
-2
-0.7% -$181
VRTX icon
94
Vertex Pharmaceuticals
VRTX
$133B
$24.9K 0.01%
55
– –
CRWD icon
95
CrowdStrike
CRWD
$226B
$24.8K 0.01%
212
– –
CB icon
96
Chubb
CB
$132B
$24.7K 0.01%
79
-1
-1% -$292
BX icon
97
Blackstone
BX
$110B
$24.5K 0.01%
159
+1
+0.6% +$152
PH icon
98
Parker-Hannifin
PH
$135B
$23.7K 0.01%
27
– –
CEG icon
99
Constellation Energy
CEG
$98.7B
$23.7K 0.01%
67
– –
BMY icon
100
Bristol-Myers Squibb
BMY
$130B
$23.6K 0.01%
438
– –
2 3
4
5 6

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SSC
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ACM
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MCM
Millstreet Capital Management Boston, Massachusetts $418M AUM 80.77% 1-Year Est. Return
MIA
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SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q4 2025 Portfolio in Review

As of Q4 2025, Howard Hughes Medical Institute held 506 positions worth $175M, up 2.4% from $171M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Trading was light in Q4 2025: portfolio turnover was 2.4%. Howard Hughes Medical Institute opened 6 new positions and exited 6, leaving the 506-position portfolio largely intact.

By sector, the portfolio is most concentrated in Technology at 2.5% of assets, down from 2.6% a quarter earlier, followed by Financials and Communication Services.

  • Howard Hughes Medical Institute's largest Q4 2025 buy was CRH: 144 shares worth $18K.
  • Howard Hughes Medical Institute added most to Omnicom Group in Q4 2025, an estimated $2.06K increase.
  • Howard Hughes Medical Institute's biggest Q4 2025 reduction was DuPont de Nemours, cutting an estimated $4.72K.
  • Howard Hughes Medical Institute fully exited Kellanova in Q4 2025, selling an estimated $4.76K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $175M portfolio in Q4 2025.
  • Howard Hughes Medical Institute opened 6 new positions and closed 6 in Q4 2025.
  • Howard Hughes Medical Institute's portfolio value rose 2.4% quarter-over-quarter to $175M.

Based on Howard Hughes Medical Institute's 13F filing for Q4 2025, filed 17 Feb 2026.