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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PGR icon
76
Progressive
PGR
$121B
$31.1K 0.02%
126
– –
PFE icon
77
Pfizer
PFE
$150B
$31.1K 0.02%
1,221
-1
-0.1% -$25
BSX icon
78
Boston Scientific
BSX
$74.5B
$31K 0.02%
318
– –
LOW icon
79
Lowe's Companies
LOW
$121B
$30.4K 0.02%
121
-1
-0.8% -$246
UNP icon
80
Union Pacific
UNP
$174B
$30.3K 0.02%
128
-2
-2% -$451
KLAC icon
81
KLA
KLAC
$272B
$30.2K 0.02%
280
– –
GILD icon
82
Gilead Sciences
GILD
$168B
$29.6K 0.02%
267
-2
-0.7% -$227
COF icon
83
Capital One
COF
$136B
$29.1K 0.02%
137
– –
PANW icon
84
Palo Alto Networks
PANW
$315B
$29.1K 0.02%
143
– –
HON icon
85
Honeywell
HON
$74.6B
$28.8K 0.02%
145
-4
-3% -$836
SYK icon
86
Stryker
SYK
$133B
$27.4K 0.02%
74
– –
DHR icon
87
Danaher
DHR
$145B
$27.2K 0.02%
137
-1
-0.7% -$199
BX icon
88
Blackstone
BX
$110B
$27K 0.02%
158
– –
ADI icon
89
Analog Devices
ADI
$187B
$26.3K 0.02%
107
– –
MDT icon
90
Medtronic
MDT
$116B
$26.3K 0.02%
276
-1
-0.4% -$92
CRWD icon
91
CrowdStrike
CRWD
$226B
$26K 0.02%
212
– –
ADP icon
92
Automatic Data Processing
ADP
$107B
$25.5K 0.02%
87
– –
WELL icon
93
Welltower
WELL
$166B
$25.5K 0.01%
143
+12
+9% +$1.97K
COP icon
94
ConocoPhillips
COP
$153B
$25.4K 0.01%
269
-6
-2% -$567
CMCSA icon
95
Comcast
CMCSA
$90.4B
$24.9K 0.01%
791
-26
-3% -$871
DE icon
96
Deere & Co
DE
$167B
$24.7K 0.01%
54
– –
TMUS icon
97
T-Mobile US
TMUS
$190B
$24.7K 0.01%
103
– –
HOOD icon
98
Robinhood
HOOD
$85.3B
$23.8K 0.01%
+166
New +$18.1K
PLD icon
99
Prologis
PLD
$134B
$22.9K 0.01%
200
– –
CB icon
100
Chubb
CB
$132B
$22.6K 0.01%
80
– –
2 3
4
5 6

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SSC
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ACM
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MCM
Millstreet Capital Management Boston, Massachusetts $418M AUM 80.77% 1-Year Est. Return
MIA
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SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.