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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
C icon
51
Citigroup
C
$231B
$40.2K 0.02%
396
-9
-2% -$854
MU icon
52
Micron Technology
MU
$1.03T
$40.2K 0.02%
240
– –
VZ icon
53
Verizon
VZ
$195B
$39.8K 0.02%
906
-3
-0.3% -$130
TMO icon
54
Thermo Fisher Scientific
TMO
$223B
$39.8K 0.02%
82
– –
AXP icon
55
American Express
AXP
$232B
$38.9K 0.02%
117
-2
-2% -$636
QCOM icon
56
Qualcomm
QCOM
$171B
$38.6K 0.02%
232
-7
-3% -$1.11K
BKNG icon
57
Booking.com
BKNG
$159B
$37.8K 0.02%
175
– –
LRCX icon
58
Lam Research
LRCX
$408B
$36.4K 0.02%
272
-5
-2% -$529
GEV icon
59
GE Vernova
GEV
$277B
$36.3K 0.02%
59
– –
BLK icon
60
Blackrock
BLK
$180B
$36.1K 0.02%
31
– –
TXN icon
61
Texas Instruments
TXN
$253B
$36K 0.02%
196
– –
AMAT icon
62
Applied Materials
AMAT
$435B
$35.4K 0.02%
173
-2
-1% -$363
SCHW
63
Charles Schwab
SCHW
$189B
$35K 0.02%
367
-1
-0.3% -$95
BA icon
64
Boeing
BA
$183B
$35K 0.02%
162
– –
TJX icon
65
TJX Companies
TJX
$169B
$34.7K 0.02%
240
-2
-0.8% -$266
ISRG icon
66
Intuitive Surgical
ISRG
$142B
$34.4K 0.02%
77
– –
NEE icon
67
NextEra Energy
NEE
$179B
$33.4K 0.02%
443
-1
-0.2% -$73
SPGI icon
68
S&P Global
SPGI
$121B
$33.1K 0.02%
68
– –
ACN icon
69
Accenture
ACN
$110B
$33K 0.02%
134
-1
-0.7% -$261
AMGN icon
70
Amgen
AMGN
$225B
$32.7K 0.02%
116
– –
ADBE icon
71
Adobe
ADBE
$103B
$32.5K 0.02%
92
-2
-2% -$718
APH icon
72
Amphenol
APH
$210B
$32.4K 0.02%
262
+1
+0.4% +$110
ANET icon
73
Arista Networks
ANET
$265B
$32.3K 0.02%
222
-1
-0.4% -$129
INTC icon
74
Intel
INTC
$509B
$31.5K 0.02%
939
+5
+0.5% +$121
ETN icon
75
Eaton
ETN
$179B
$31.4K 0.02%
84
-1
-1% -$364
1 2
3
4 5

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ACM
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MCM
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MIA
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SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.