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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+10.63%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$251M
AUM Growth
+$48.7M
Cap. Flow
+$25.5M
Cap. Flow %
10.17%
Top 10 Hldgs %
97.11%
Holding
502
New
500
Increased
1
Reduced
–
Closed
1

Top Buys

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$15.6M
2
MSFT icon
Microsoft
MSFT
+$700K
3
NVDA icon
NVIDIA
NVDA
+$665K
4
AAPL icon
Apple
AAPL
+$653K
5
AMZN icon
Amazon
AMZN
+$403K

Top Sells

Rank Stock Value
1
BIOA
BioAge Labs
BIOA
+$428K

Sector Composition

Rank Sector Weight
1 Technology 1.55%
2 Financials 0.62%
3 Consumer Discretionary 0.47%
4 Communication Services 0.44%
5 Healthcare 0.42%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
NWS icon
501
News Corp Class B
NWS
$17.7B
$823 ﹤0.01%
+24
New +$760
BIOA
502
BioAge Labs
BIOA
$481M
– –
-113,765
Closed -$428K
17 18 19 20
21

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Howard Hughes Medical Institute's Q2 2025 Portfolio in Review

As of Q2 2025, Howard Hughes Medical Institute held 502 positions worth $251M, up 24% from $202M the previous quarter. Its ten largest holdings account for 97% of the portfolio.

Howard Hughes Medical Institute deployed $25.5M of net new capital in Q2 2025, opening 500 new positions and adding to 1 existing holding. Its largest new stake was Microsoft: 1,611 shares worth $801K.

By sector, the portfolio is most concentrated in Technology at 1.6% of assets, followed by Financials and Consumer Discretionary.

On the sell side, the most notable exit was BioAge Labs, an estimated $428K sold.

  • Howard Hughes Medical Institute's largest Q2 2025 buy was Microsoft: 1,611 shares worth $801K.
  • Howard Hughes Medical Institute added most to State Street SPDR S&P 500 ETF Trust in Q2 2025, an estimated $15.6M increase.
  • Howard Hughes Medical Institute fully exited BioAge Labs in Q2 2025, selling an estimated $428K.
  • Howard Hughes Medical Institute's ten largest holdings make up 97% of its $251M portfolio in Q2 2025.
  • Howard Hughes Medical Institute opened 500 new positions and closed 1 in Q2 2025.
  • Howard Hughes Medical Institute's portfolio value rose 24% quarter-over-quarter to $251M.

Based on Howard Hughes Medical Institute's 13F filing for Q2 2025, filed 14 Aug 2025.