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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
BAC icon
26
Bank of America
BAC
$453B
$75.5K 0.04%
1,463
+31
+2% +$1.51K
GE icon
27
GE Aerospace
GE
$379B
$68.6K 0.04%
228
-3
-1% -$820
UNH icon
28
UnitedHealth
UNH
$364B
$67.3K 0.04%
195
-3
-2% -$907
CVX icon
29
Chevron
CVX
$386B
$64.3K 0.04%
414
+53
+15% +$8.21K
CSCO icon
30
Cisco
CSCO
$488B
$58.2K 0.03%
851
-9
-1% -$613
WFC icon
31
Wells Fargo
WFC
$269B
$57.7K 0.03%
688
-23
-3% -$1.86K
AMD icon
32
Advanced Micro Devices
AMD
$788B
$56.5K 0.03%
349
-1
-0.3% -$161
IBM icon
33
IBM
IBM
$222B
$56.4K 0.03%
200
+1
+0.5% +$262
KO icon
34
Coca-Cola
KO
$373B
$55.2K 0.03%
832
-4
-0.5% -$275
GS icon
35
Goldman Sachs
GS
$302B
$52.6K 0.03%
66
-1
-1% -$741
ABT icon
36
Abbott
ABT
$192B
$50.1K 0.03%
374
– –
CRM icon
37
Salesforce
CRM
$158B
$48.8K 0.03%
206
– –
CAT icon
38
Caterpillar
CAT
$393B
$48.2K 0.03%
101
-2
-2% -$854
RTX icon
39
RTX Corp
RTX
$300B
$48K 0.03%
287
– –
LIN icon
40
Linde
LIN
$221B
$48K 0.03%
101
-1
-1% -$473
MCD icon
41
McDonald's
MCD
$195B
$46.8K 0.03%
154
– –
MRK icon
42
Merck
MRK
$328B
$45.1K 0.03%
537
-9
-2% -$741
DIS icon
43
Walt Disney
DIS
$178B
$44.3K 0.03%
387
-3
-0.8% -$353
UBER icon
44
Uber
UBER
$154B
$43.9K 0.03%
448
-3
-0.7% -$281
T icon
45
AT&T
T
$166B
$43.4K 0.03%
1,536
-21
-1% -$596
APP icon
46
Applovin
APP
$102B
$41.7K 0.02%
+58
New +$26.7K
MS icon
47
Morgan Stanley
MS
$342B
$41.5K 0.02%
261
-6
-2% -$886
PEP icon
48
PepsiCo
PEP
$189B
$41.4K 0.02%
295
-1
-0.3% -$143
INTU icon
49
Intuit
INTU
$91.6B
$41K 0.02%
60
– –
NOW icon
50
ServiceNow
NOW
$129B
$40.5K 0.02%
220
– –
1
2
3 4 5

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ACM
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MCM
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MIA
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SP
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VIS
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.