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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
NCLH icon
451
Norwegian Cruise Line
NCLH
$8.69B
$2.39K ﹤0.01%
97
+2
+2% +$49
SJM icon
452
J.M. Smucker
SJM
$12.7B
$2.39K ﹤0.01%
22
– –
AIZ icon
453
Assurant
AIZ
$13.9B
$2.38K ﹤0.01%
11
– –
MOS icon
454
The Mosaic Company
MOS
$7.18B
$2.36K ﹤0.01%
68
– –
AKAM icon
455
Akamai
AKAM
$17.6B
$2.35K ﹤0.01%
31
-1
-3% -$77
HST icon
456
Host Hotels & Resorts
HST
$15.6B
$2.35K ﹤0.01%
138
-13
-9% -$216
DAY
457
DELISTED
Dayforce
DAY
$2.34K ﹤0.01%
34
– –
BXP icon
458
Boston Properties
BXP
$10.8B
$2.31K ﹤0.01%
31
– –
HII icon
459
Huntington Ingalls Industries
HII
$12.9B
$2.3K ﹤0.01%
8
– –
FDS icon
460
Factset
FDS
$9.89B
$2.29K ﹤0.01%
8
– –
JBHT icon
461
JB Hunt Transport Services
JBHT
$25.9B
$2.28K ﹤0.01%
17
– –
SOLV icon
462
Solventum
SOLV
$14.5B
$2.26K ﹤0.01%
31
+2
+7% +$147
PNW icon
463
Pinnacle West Capital
PNW
$12.2B
$2.24K ﹤0.01%
25
+1
+4% +$90
JKHY icon
464
Jack Henry & Associates
JKHY
$10.8B
$2.23K ﹤0.01%
15
– –
IPG
465
DELISTED
Interpublic Group of Companies
IPG
$2.21K ﹤0.01%
79
-1
-1% -$26
IVZ icon
466
Invesco
IVZ
$13.9B
$2.2K ﹤0.01%
96
– –
RVTY icon
467
Revvity
RVTY
$13.2B
$2.19K ﹤0.01%
25
-1
-4% -$91
HAS icon
468
Hasbro
HAS
$13.4B
$2.12K ﹤0.01%
28
– –
MOH icon
469
Molina Healthcare
MOH
$10.8B
$2.1K ﹤0.01%
11
– –
PAYC icon
470
Paycom
PAYC
$9.52B
$2.08K ﹤0.01%
10
– –
ALB icon
471
Albemarle
ALB
$15.1B
$2.03K ﹤0.01%
25
– –
AES icon
472
AES
AES
$10.5B
$2.01K ﹤0.01%
153
– –
GNRC icon
473
Generac Holdings
GNRC
$13.1B
$2.01K ﹤0.01%
12
– –
MRNA icon
474
Moderna
MRNA
$25.4B
$1.91K ﹤0.01%
74
+1
+1% +$28
TECH icon
475
Bio-Techne
TECH
$11.3B
$1.89K ﹤0.01%
34
– –
17 18
19
20 21

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SSC
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ACM
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MCM
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MIA
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SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.