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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
WAT icon
401
Waters Corp
WAT
$40.9B
$3.6K ﹤0.01%
12
– –
INVH icon
402
Invitation Homes
INVH
$17.7B
$3.58K ﹤0.01%
122
-1
-0.8% -$31
FTV icon
403
Fortive
FTV
$18.6B
$3.58K ﹤0.01%
73
– –
ROL icon
404
Rollins
ROL
$17.6B
$3.52K ﹤0.01%
60
– –
MAA icon
405
Mid-America Apartment Communities
MAA
$15.4B
$3.49K ﹤0.01%
25
– –
DOW icon
406
Dow Inc
DOW
$22.1B
$3.48K ﹤0.01%
152
– –
ESS icon
407
Essex Property Trust
ESS
$18.1B
$3.48K ﹤0.01%
13
– –
OMC icon
408
Omnicom Group
OMC
$23.5B
$3.42K ﹤0.01%
42
– –
GEN icon
409
Gen Digital
GEN
$17.1B
$3.41K ﹤0.01%
120
+3
+3% +$90
IFF icon
410
International Flavors & Fragrances
IFF
$21.4B
$3.38K ﹤0.01%
55
– –
TSN icon
411
Tyson Foods
TSN
$19.6B
$3.31K ﹤0.01%
61
– –
CHRW icon
412
C.H. Robinson
CHRW
$17.1B
$3.31K ﹤0.01%
25
– –
TXT icon
413
Textron
TXT
$15.3B
$3.29K ﹤0.01%
39
– –
ZBRA icon
414
Zebra Technologies
ZBRA
$17.9B
$3.27K ﹤0.01%
11
– –
DECK icon
415
Deckers Outdoor
DECK
$12.4B
$3.24K ﹤0.01%
32
– –
HOLX
416
DELISTED
Hologic
HOLX
$3.24K ﹤0.01%
48
– –
CLX icon
417
Clorox
CLX
$12.8B
$3.21K ﹤0.01%
26
– –
ALLE icon
418
Allegion
ALLE
$14.1B
$3.19K ﹤0.01%
18
– –
KIM icon
419
Kimco Realty
KIM
$16.2B
$3.19K ﹤0.01%
146
– –
BBY icon
420
Best Buy
BBY
$17.5B
$3.18K ﹤0.01%
42
– –
LII icon
421
Lennox International
LII
$14.5B
$3.18K ﹤0.01%
6
– –
MAS icon
422
Masco
MAS
$14.7B
$3.17K ﹤0.01%
45
– –
EG icon
423
Everest Group
EG
$13.9B
$3.15K ﹤0.01%
9
– –
CF icon
424
CF Industries
CF
$18.2B
$3.14K ﹤0.01%
35
-2
-5% -$178
VTRS icon
425
Viatris
VTRS
$18.5B
$3.11K ﹤0.01%
314
+25
+9% +$243
15 16
17
18 19

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SSC
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ACM
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MCM
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MIA
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SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.